DNA conformation is determined by economics in the hydration of phosphate groups View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-11-01

AUTHORS

Wolfram Saenger, William N. Hunter, Olga Kennard

ABSTRACT

Mixed sequence DNA can exist in two right-handed and one left-handed double helical conformations—A, B and Z1–3. Under conditions of high water activity the B conformation prevails. If the water activity is reduced on addition of salt or organic solvents, transformation occurs to A-DNA or, in DNAs with alternating purine-pyrimidine sequences, to the left-handed Z-DNA. In crystal structure analyses of oligonucleotides, the free oxygen atoms of adjacent phosphate groups along the polynucleotide chain in B-DNA are found at least 6.6 Å apart and individually hydrated4 whereas they are as close as 5.3 Å in A-DNA and 4.4 Å in Z-DNA, and bridged by water molecules5–7. We suggest that this more economical hydration in A- and Z-DNA compared with B-DNA is the underlying cause of B → A and B → Z transitions. More... »

PAGES

385-388

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/324385a0

DOI

http://dx.doi.org/10.1038/324385a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020341365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3785407


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