Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-11

AUTHORS

Toshio Hirano, Kiyoshi Yasukawa, Hisashi Harada, Tetsuya Taga, Yasuo Watanabe, Tadashi Matsuda, Shin-ichiro Kashiwamura, Koichi Nakajima, Koichi Koyama, Akihiro Iwamatsu, Susumu Tsunasawa, Fumio Sakiyama, Hiroshi Matsui, Yoshiyuki Takahara, Tadatsugu Taniguchi, Tadamitsu Kishimoto

ABSTRACT

When stimulated with antigen, B cells are influenced by T cells to proliferate and differentiate into antibody-forming cells. Since it was reported1,2 that soluble factors could replace certain functions of helper T cells in the antibody response, several different kinds of lymphokines and monokines have been reported in B-cell growth and differentiation3,4. Among these, human B-cell differentiation factor (BCDF or BSF-2) has been shown to induce the final maturation of B cells into immunoglobulin-secreting cells5–8. BSF-2 was purified to homogeneity9 and its partial NH2-terminal amino-acid sequence was determined10. These studies indicated that BSF-2 is functionally and structurally unlike other known proteins. Here, we report the molecular cloning, structural analysis and functional expression of the cDNA encoding human BSF-2. The primary sequence of BSF-2 deduced from the cDNA reveals that BSF-2 is a novel interleukin consisting of 184 amino acids. More... »

PAGES

73-76

Journal

TITLE

Nature

ISSUE

6092

VOLUME

324

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/324073a0

    DOI

    http://dx.doi.org/10.1038/324073a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032660396

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3491322


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