Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-11

AUTHORS

Tatsuo Kinashi, Nobuyuki Harada, Eva Severinson, Toshizumi Tanabe, Paschalis Sideras, Mikio Konishi, Chihiro Azuma, Akira Tominaga, Susanne Bergstedt-Lindqvist, Masazumi Takahashi, Fumihiko Matsuda, Yoshio Yaoita, Kiyoshi Takatsu, Tasuku Honjo

ABSTRACT

Proliferation and maturation of antigen-stimulated B cells are regulated by several soluble factors derived from macrophages and T cells1,2. These soluble factors are functionally divided into two groups: B-cell growth factor (BCGF), thought to be involved in B-cell proliferation; and B-cell differentiation factor (BCDF), responsible for maturation of activated B cells into immunoglobulin-secreting cells3–6. This classification needs to be re-examined in the light of the recent cloning of complementary DNA encoding IgG1 induction factor (interleukin-4, IL-4) from the 2.19 mouse T-cell line7. Recombinant IL-4 has BCGF and BCDF activities and affects B cells, T cells and mast cells (refs 7, 8; our unpublished data). Another well-characterized B-cell factor is T-cell replacing factor (TRF)9–12, which, when secreted by the murine T-cell hybridoma B151K12, is defined by two activities10–12: induction of IgM secretion by BCL1 leukaemic B-cell line; and induction of secondary anti-dinitrophenol (DNP) immunoglobulin G (IgG) synthesis in vitro by DNP-primed B cells. Although TRF from B151K12 was classified as BCDF, purified TRF has BCGF-II activity13. To elucidate the molecular properties of TRF we isolated cDNA encoding TRF from the 2.19 T-cell line and report here the structure and multiple activities of this lymphokine. More... »

PAGES

70-73

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/324070a0

DOI

http://dx.doi.org/10.1038/324070a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046262209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3024009


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