Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-10

AUTHORS

Elizabeth Robertson, Allan Bradley, Michael Kuehn, Martin Evans

ABSTRACT

Embryonic stem cells isolated directly from mouse embryos can be cultured for long periods in vitro and subsequently repopulate the germ line in chimaeric mice. During the culture period these embryonic cells are accessible for experimental genetic manipulation. Here we report the use of retroviral vectors to introduce exogenous DNA sequences into a stem-cell line and show that these modified cells contribute extensively to the somatic and germ-cell lineages in chimaeric mice. Compared with current methods for manipulation of the mouse genome, this approach has the advantage that powerful somatic-cell genetic techniques can be used to modify and to select cells with germ-line potential, allowing the derivation of transgenic strains with pre-determined genetic changes. We have by this means inserted many proviral vector sequences that provide new chromosomal molecular markers for linkage studies in the mouse and that also may cause insertional mutations. More... »

PAGES

445-448

Journal

TITLE

Nature

ISSUE

6087

VOLUME

323

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/323445a0

    DOI

    http://dx.doi.org/10.1038/323445a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047908913

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3762693


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