Bovine papillomavirus genome elicits skin tumours in transgenic mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-08

AUTHORS

Mark Lacey, Susan Alpert, Douglas Hanahan

ABSTRACT

Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA. More... »

PAGES

609-612

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/322609a0

DOI

http://dx.doi.org/10.1038/322609a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050796607

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3018579


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