A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-07

AUTHORS

Ilan Bank, Ronald A. DePinho, Michael B. Brenner, Judy Cassimeris, Frederick W. Alt, Leonard Chess

ABSTRACT

The known T-cell receptors (TCRs) involved in the recognition of antigen and major histocompatibility complex (MHC) molecules are glycoproteins comprised of polymorphic disulphide-linked α-and β-chains1–5. The genes encoding these chains are homologous to immunoglobulin genes and consist of V (variable), J(joining) and C (constant) regions that rearrange during development6–13. TCRs are expressed relatively late in thymocyte development and only in association with an invariant molecular complex of proteins termed T3 (refs 3, 14). Immature thymocytes do not express the TCR–T3 complex but do express messenger RNA encoding a third rearranging T-cell receptor-like gene, termed Tγ (refs 13,15–20). Here we report a clone of normal immature T4−T8− human thymocytes, designated CII, which does not express mature mRNA for Tα or Tβ genes, but does express high levels of Tγ mRNA. This clone also expresses high levels of surface T3, and antibodies to T3 induce immunologically relevant functions in CII cells. Immunoprecipitation of CII surface-labelled proteins with anti-T3 co-precipitates a T3 molecular complex together with two additional and novel peptides of relative molecular mass (Mr) 44,000 (44K) and 62,000 (62K). More... »

PAGES

179-181

References to SciGraph publications

  • 1986-07. Identification of a putative second T-cell receptor in NATURE
  • 1977-07. Long term culture of tumour-specific cytotoxic T cells in NATURE
  • 1984-12. Primary structure of human T-cell receptor α-chain in NATURE
  • 1984-11. Immunoglobulin-like nature of the α-chain of a human T-cell antigen/MHC receptor in NATURE
  • 1984-03. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains in NATURE
  • 1984-11. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes in NATURE
  • 1985-03. Developmental regulation of T-cell receptor gene expression in NATURE
  • 1984-11. Homology of Ti α-subunit of a T-cell antigen–MHC receptor with immunoglobulin in NATURE
  • 1984-11. A third type of murine T-cell receptor gene in NATURE
  • 1984-03. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins in NATURE
  • 1984-03. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins in NATURE
  • 1985-06. Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor β-chain gene in NATURE
  • 1986-02. Differential expression of myc family genes during murine development in NATURE
  • 1985-06-01. Expression of genes of the T-cell antigen receptor complex in precursor thymocytes in NATURE
  • 1985-08-01. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer in NATURE
  • 1984-06. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/322179a0

    DOI

    http://dx.doi.org/10.1038/322179a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035159334

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3487737


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