CpG-rich islands and the function of DNA methylation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-05

AUTHORS

Adrian P. Bird

ABSTRACT

It is likely that most vertebrate genes are associated with 'HTF islands'--DNA sequences in which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually lack islands. The contrast between islands and the remainder of the genome may identify sequences that are to be constantly available in the nucleus. DNA methylation appears to be involved in this function, rather than with activation of tissue specific genes. More... »

PAGES

209-213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/321209a0

DOI

http://dx.doi.org/10.1038/321209a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022096390

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2423876


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