Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-05

AUTHORS

L. W. Haynes, A. R. Kay, K.-W. Yau

ABSTRACT

The plasma membrane of retinal rod outer segments contains a cyclic GMP-activated conductance1–6 which appears to be the light-sensitive conductance involved in phototransduction7. Recently, it has been found that this conductance is partially blocked by Mg2+ (refs 3, 8, 9) and Ca2+ (refs 3, 4, 8–11) at physiological concentrations, thus possibly accounting for the absence of observable single-channel activity in excised membrane patches1,3,8 and for the unusually small apparent unit conductance deduced from noise measurements on intact cells4,10,12,13. We now report that, as expected from this idea, single cGMP-activated channel activity can be detected from an excised rod membrane patch in the absence of divalent cations. The most prominent unitary current had a mean conductance of ∼25 pS. Both individual channel openings (mean open time ∼1 ms) and short bursts of openings (mean burst duration of about a few milliseconds) were observed. In addition, there were smaller events which probably represented other states of the conductance. The mean current increased with the third power of cGMP concentration, suggesting that there are at least three cGMP-binding sites on the channel molecule. With 0.2 mM Mg2+ in the cGMP-containing solution, a flickering block of the open channel was observed; the effect of Ca2+ was similar. The results resolve a puzzle about the light-sensitive conductance by demonstrating that it is an aqueous pore rather than a carrier. More... »

PAGES

66-70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/321066a0

DOI

http://dx.doi.org/10.1038/321066a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021867825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2422558


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ambystoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bufo marinus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic GMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnesium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photoreceptor Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rod Cell Outer Segment", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.176731.5", 
          "name": [
            "Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haynes", 
        "givenName": "L. W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.176731.5", 
          "name": [
            "Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kay", 
        "givenName": "A. R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.176731.5", 
          "name": [
            "Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yau", 
        "givenName": "K.-W.", 
        "id": "sg:person.01130063732.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130063732.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/317061a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003345839", 
          "https://doi.org/10.1038/317061a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/307462a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047554393", 
          "https://doi.org/10.1038/307462a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/311661a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000450815", 
          "https://doi.org/10.1038/311661a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/317252a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016460749", 
          "https://doi.org/10.1038/317252a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309453a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015077827", 
          "https://doi.org/10.1038/309453a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/294464a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039529526", 
          "https://doi.org/10.1038/294464a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/292502a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003955802", 
          "https://doi.org/10.1038/292502a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00580798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051298100", 
          "https://doi.org/10.1007/bf00580798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313310a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049661228", 
          "https://doi.org/10.1038/313310a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313579a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027345077", 
          "https://doi.org/10.1038/313579a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01871455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027122527", 
          "https://doi.org/10.1007/bf01871455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309352a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006352679", 
          "https://doi.org/10.1038/309352a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1986-05", 
    "datePublishedReg": "1986-05-01", 
    "description": "The plasma membrane of retinal rod outer segments contains a cyclic GMP-activated conductance1\u20136 which appears to be the light-sensitive conductance involved in phototransduction7. Recently, it has been found that this conductance is partially blocked by Mg2+ (refs 3, 8, 9) and Ca2+ (refs 3, 4, 8\u201311) at physiological concentrations, thus possibly accounting for the absence of observable single-channel activity in excised membrane patches1,3,8 and for the unusually small apparent unit conductance deduced from noise measurements on intact cells4,10,12,13. We now report that, as expected from this idea, single cGMP-activated channel activity can be detected from an excised rod membrane patch in the absence of divalent cations. The most prominent unitary current had a mean conductance of \u223c25 pS. Both individual channel openings (mean open time \u223c1 ms) and short bursts of openings (mean burst duration of about a few milliseconds) were observed. In addition, there were smaller events which probably represented other states of the conductance. The mean current increased with the third power of cGMP concentration, suggesting that there are at least three cGMP-binding sites on the channel molecule. With 0.2 mM Mg2+ in the cGMP-containing solution, a flickering block of the open channel was observed; the effect of Ca2+ was similar. The results resolve a puzzle about the light-sensitive conductance by demonstrating that it is an aqueous pore rather than a carrier.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/321066a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6065", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "321"
      }
    ], 
    "keywords": [
      "noise measurements", 
      "short bursts", 
      "third power", 
      "channel molecules", 
      "current", 
      "conductance", 
      "aqueous pores", 
      "mean currents", 
      "light-sensitive conductance", 
      "bursts", 
      "unit conductance", 
      "measurements", 
      "channel activity", 
      "cGMP-binding sites", 
      "open channels", 
      "membrane patches", 
      "mean conductance", 
      "plasma membrane", 
      "cyclic GMP", 
      "state", 
      "carriers", 
      "rod outer segments", 
      "individual channel openings", 
      "power", 
      "molecules", 
      "channels", 
      "puzzle", 
      "rod outer segment membranes", 
      "retinal rod outer segments", 
      "single-channel activity", 
      "outer segment membranes", 
      "membrane", 
      "outer segments", 
      "physiological concentrations", 
      "cations", 
      "channel opening", 
      "cGMP concentration", 
      "excised patches", 
      "GMP", 
      "divalent cations", 
      "flickering block", 
      "effect of Ca2", 
      "segment membranes", 
      "cGMP", 
      "unitary currents", 
      "small events", 
      "Ca2", 
      "activity", 
      "opening", 
      "effect", 
      "pores", 
      "Mg2", 
      "concentration", 
      "absence", 
      "patches", 
      "solution", 
      "results", 
      "sites", 
      "addition", 
      "idea", 
      "events", 
      "block", 
      "segments", 
      "single cGMP"
    ], 
    "name": "Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane", 
    "pagination": "66-70", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021867825"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/321066a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2422558"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/321066a0", 
      "https://app.dimensions.ai/details/publication/pub.1021867825"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_189.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/321066a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/321066a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/321066a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/321066a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/321066a0'


 

This table displays all metadata directly associated to this object as RDF triples.

229 TRIPLES      21 PREDICATES      113 URIs      93 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/321066a0 schema:about N06e685718499404698138ae5e43c09af
2 N0856989ebbbf48cb8cb828a92efd90d6
3 N4f81aaffbad342dda492113370ce499a
4 N89c8b9456bdd40cfa7a841064ac02412
5 N8e38bae2055b46c4af71eba2f131ec7e
6 Naee8df5b794143b49e035cf47b833636
7 Nbff51588d7f644d08acb2bae59f84479
8 Nd76322f69b52420fa56d9789b22c7c64
9 Neb2d614b47f84be0a6e0e238b956da1e
10 Nf5d7cbbc909140d89028a81b856a75d7
11 Nfbf64546d9c74e1498112a41584d0aae
12 anzsrc-for:02
13 anzsrc-for:0299
14 schema:author N59ad34e144f240358a7186fb94598de1
15 schema:citation sg:pub.10.1007/bf00580798
16 sg:pub.10.1007/bf01871455
17 sg:pub.10.1038/292502a0
18 sg:pub.10.1038/294464a0
19 sg:pub.10.1038/307462a0
20 sg:pub.10.1038/309352a0
21 sg:pub.10.1038/309453a0
22 sg:pub.10.1038/311661a0
23 sg:pub.10.1038/313310a0
24 sg:pub.10.1038/313579a0
25 sg:pub.10.1038/317061a0
26 sg:pub.10.1038/317252a0
27 schema:datePublished 1986-05
28 schema:datePublishedReg 1986-05-01
29 schema:description The plasma membrane of retinal rod outer segments contains a cyclic GMP-activated conductance1–6 which appears to be the light-sensitive conductance involved in phototransduction7. Recently, it has been found that this conductance is partially blocked by Mg2+ (refs 3, 8, 9) and Ca2+ (refs 3, 4, 8–11) at physiological concentrations, thus possibly accounting for the absence of observable single-channel activity in excised membrane patches1,3,8 and for the unusually small apparent unit conductance deduced from noise measurements on intact cells4,10,12,13. We now report that, as expected from this idea, single cGMP-activated channel activity can be detected from an excised rod membrane patch in the absence of divalent cations. The most prominent unitary current had a mean conductance of ∼25 pS. Both individual channel openings (mean open time ∼1 ms) and short bursts of openings (mean burst duration of about a few milliseconds) were observed. In addition, there were smaller events which probably represented other states of the conductance. The mean current increased with the third power of cGMP concentration, suggesting that there are at least three cGMP-binding sites on the channel molecule. With 0.2 mM Mg2+ in the cGMP-containing solution, a flickering block of the open channel was observed; the effect of Ca2+ was similar. The results resolve a puzzle about the light-sensitive conductance by demonstrating that it is an aqueous pore rather than a carrier.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N57e77e1d2f6e4d6283e9ca875ba7dd5a
33 N897947c3824148be8178a28cb3d7b4e8
34 sg:journal.1018957
35 schema:keywords Ca2
36 GMP
37 Mg2
38 absence
39 activity
40 addition
41 aqueous pores
42 block
43 bursts
44 cGMP
45 cGMP concentration
46 cGMP-binding sites
47 carriers
48 cations
49 channel activity
50 channel molecules
51 channel opening
52 channels
53 concentration
54 conductance
55 current
56 cyclic GMP
57 divalent cations
58 effect
59 effect of Ca2
60 events
61 excised patches
62 flickering block
63 idea
64 individual channel openings
65 light-sensitive conductance
66 mean conductance
67 mean currents
68 measurements
69 membrane
70 membrane patches
71 molecules
72 noise measurements
73 open channels
74 opening
75 outer segment membranes
76 outer segments
77 patches
78 physiological concentrations
79 plasma membrane
80 pores
81 power
82 puzzle
83 results
84 retinal rod outer segments
85 rod outer segment membranes
86 rod outer segments
87 segment membranes
88 segments
89 short bursts
90 single cGMP
91 single-channel activity
92 sites
93 small events
94 solution
95 state
96 third power
97 unit conductance
98 unitary currents
99 schema:name Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane
100 schema:pagination 66-70
101 schema:productId N1342c13a940a495a96069459df28a05c
102 N42f256577658483d8d9edd9c09872b23
103 Nec54f7430d03402ab52bcbea5be43ed4
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021867825
105 https://doi.org/10.1038/321066a0
106 schema:sdDatePublished 2022-12-01T06:19
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N836fc2b03f33479e9cfd134d6741dbe7
109 schema:url https://doi.org/10.1038/321066a0
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N06e685718499404698138ae5e43c09af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Photoreceptor Cells
115 rdf:type schema:DefinedTerm
116 N0856989ebbbf48cb8cb828a92efd90d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Magnesium
118 rdf:type schema:DefinedTerm
119 N1342c13a940a495a96069459df28a05c schema:name pubmed_id
120 schema:value 2422558
121 rdf:type schema:PropertyValue
122 N42f256577658483d8d9edd9c09872b23 schema:name doi
123 schema:value 10.1038/321066a0
124 rdf:type schema:PropertyValue
125 N4c81c47c67e14adb87f4a6527a1bffd8 rdf:first sg:person.01130063732.09
126 rdf:rest rdf:nil
127 N4f81aaffbad342dda492113370ce499a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name In Vitro Techniques
129 rdf:type schema:DefinedTerm
130 N57e77e1d2f6e4d6283e9ca875ba7dd5a schema:volumeNumber 321
131 rdf:type schema:PublicationVolume
132 N59ad34e144f240358a7186fb94598de1 rdf:first N82bce984c325451286c148d3482cea49
133 rdf:rest Nf0c88f218fc04257bbc02d1c8b7e2210
134 N6093a70b72f84db398e6f95b9097e155 schema:affiliation grid-institutes:grid.176731.5
135 schema:familyName Kay
136 schema:givenName A. R.
137 rdf:type schema:Person
138 N82bce984c325451286c148d3482cea49 schema:affiliation grid-institutes:grid.176731.5
139 schema:familyName Haynes
140 schema:givenName L. W.
141 rdf:type schema:Person
142 N836fc2b03f33479e9cfd134d6741dbe7 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 N897947c3824148be8178a28cb3d7b4e8 schema:issueNumber 6065
145 rdf:type schema:PublicationIssue
146 N89c8b9456bdd40cfa7a841064ac02412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cyclic GMP
148 rdf:type schema:DefinedTerm
149 N8e38bae2055b46c4af71eba2f131ec7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Animals
151 rdf:type schema:DefinedTerm
152 Naee8df5b794143b49e035cf47b833636 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Bufo marinus
154 rdf:type schema:DefinedTerm
155 Nbff51588d7f644d08acb2bae59f84479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Rod Cell Outer Segment
157 rdf:type schema:DefinedTerm
158 Nd76322f69b52420fa56d9789b22c7c64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Membrane Potentials
160 rdf:type schema:DefinedTerm
161 Neb2d614b47f84be0a6e0e238b956da1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cell Membrane
163 rdf:type schema:DefinedTerm
164 Nec54f7430d03402ab52bcbea5be43ed4 schema:name dimensions_id
165 schema:value pub.1021867825
166 rdf:type schema:PropertyValue
167 Nf0c88f218fc04257bbc02d1c8b7e2210 rdf:first N6093a70b72f84db398e6f95b9097e155
168 rdf:rest N4c81c47c67e14adb87f4a6527a1bffd8
169 Nf5d7cbbc909140d89028a81b856a75d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Ion Channels
171 rdf:type schema:DefinedTerm
172 Nfbf64546d9c74e1498112a41584d0aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Ambystoma
174 rdf:type schema:DefinedTerm
175 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
176 schema:name Physical Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
179 schema:name Other Physical Sciences
180 rdf:type schema:DefinedTerm
181 sg:journal.1018957 schema:issn 0028-0836
182 1476-4687
183 schema:name Nature
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01130063732.09 schema:affiliation grid-institutes:grid.176731.5
187 schema:familyName Yau
188 schema:givenName K.-W.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130063732.09
190 rdf:type schema:Person
191 sg:pub.10.1007/bf00580798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051298100
192 https://doi.org/10.1007/bf00580798
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/bf01871455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027122527
195 https://doi.org/10.1007/bf01871455
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/292502a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003955802
198 https://doi.org/10.1038/292502a0
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/294464a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039529526
201 https://doi.org/10.1038/294464a0
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/307462a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047554393
204 https://doi.org/10.1038/307462a0
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/309352a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006352679
207 https://doi.org/10.1038/309352a0
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/309453a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015077827
210 https://doi.org/10.1038/309453a0
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/311661a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000450815
213 https://doi.org/10.1038/311661a0
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/313310a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049661228
216 https://doi.org/10.1038/313310a0
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/313579a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027345077
219 https://doi.org/10.1038/313579a0
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/317061a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003345839
222 https://doi.org/10.1038/317061a0
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/317252a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016460749
225 https://doi.org/10.1038/317252a0
226 rdf:type schema:CreativeWork
227 grid-institutes:grid.176731.5 schema:alternateName Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA
228 schema:name Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA
229 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...