Reduction in number of immunostained GABAergic neurones in deprived-eye dominance columns of monkey area 17 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-04

AUTHORS

S. H. C. Hendry, E. G. Jones

ABSTRACT

The primary visual cortex (area 17) of the Old World monkey is divided into alternating right- and left-eye dominance columns1–3 that are highly modifiable by visual experience during a critical period in development but display little morphological or physiological plasticity during adult life4,5. However, changes in immunocytochemical staining for a calcium/calmodulin-dependent protein kinase occur in visual cortical neurones of adult monkeys after brief monocular deprivation6 and concentrations of putative neurotransmitters or their related enzymes can be altered with changes in neuronal activity in other systems7–9. We therefore examined the effects of monocular deprivation on the immunocytochemical staining for γ-aminobutyric acid (GABA) and its synthetic enzyme, glutamic acid decarboxylase (GAD), in adult monkey area 17. The staining for GABA and GAD in neuronal somata and terminals was markedly reduced within ocular dominance columns associated with a removed or a visually deprived eye, suggesting that the GABA concentration in cortical neurones may depend on their levels of activity. Thus area 17 of adult monkeys may retain a greater degree of plasticity than previously recognized and sensory experience can profoundly affect transmitter levels, in the cortex, apparently by regulating levels of a synthetic enzyme. More... »

PAGES

750-753

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/320750a0

DOI

http://dx.doi.org/10.1038/320750a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008253410

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3703001


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