cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-04

AUTHORS

Christer Betsholtz, Ann Johnsson, Carl-Henrik Heldin, Bengt Westermark, Peter Lind, Mickey S. Urdea, Roger Eddy, Thomas B. Shows, Karen Philpott, Andrew L. Mellor, Timothy J. Knott, James Scott

ABSTRACT

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA. More... »

PAGES

695-699

Journal

TITLE

Nature

ISSUE

6064

VOLUME

320

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/320695a0

    DOI

    http://dx.doi.org/10.1038/320695a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032189457

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3754619


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/320695a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/320695a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/320695a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/320695a0'


     

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