Activation of meiosis and sporulation by repression of the RME1 product in yeast View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-02

AUTHORS

Aaron P. Mitchell, Ira Herskowitz

ABSTRACT

The ability of the yeast Saccharomyces cerevisiae to enter meiosis and sporulate is conferred by the a1-alpha 2 regulatory activity of the mating-type locus. We have cloned the RME1 gene and show that: the RME1 transcript is repressed by a1-alpha 2 in a/alpha cells; overexpression of the RME1 product in a/alpha cells blocks sporulation; and inactivation of RME1 by a null mutation constructed in vitro permits cells lacking a1-alpha 2 activity to sporulate. The RME1 product thus inhibits meiosis; the mating-type locus permits entry into meiosis by repression of RME1. More... »

PAGES

738

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/319738a0

DOI

http://dx.doi.org/10.1038/319738a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030020403

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3513021


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