Ontology type: schema:ScholarlyArticle
1986-02
AUTHORS ABSTRACTIn cardiac muscle the exchange of intracellular Ca2+ for extracellular Na+ is an important transport mechanism for regulation of the intracellular free Ca2+ concentration ([Ca]i) and hence the contractile strength of the heart (ref. 1 ; for reviews see refs 2–4). Due to its stoichiometry of ≥3:l Na+/Ca2+ (refs 3,5), Na-Ca exchange is supposed to generate a current across the cell membrane. It is thought that such a current may contribute to cardiac action potential and physiological or pathological pacemaker activity6,7. Although the occurrence of Na-Ca exchange is well documented, a membrane current generated by this transport has not been identified unequivocally. Previous attempts to detect such a current-in multicellular preparations, for example, by measuring small current differences after varying the extracellular ionic composition8, although providing evidence, did not rule out other possible interpretations. Here we demonstrate that a transient rise in [Ca]i caused by release of Ca from sarcoplasmic reticulum (SR) generates a membrane current in cardiac myocytes. The dependence of this current on the transmembrane gradients for Na+ and Ca2+ and on membrane potential meets the criteria for a current produced by electrogenic Na-Ca exchange. Cyclic activation of this current by release of Ca from the SR can cause maintained spontaneous activity, suggesting that Na-Ca exchange contributes to certain forms of cardiac pacemaking. More... »
PAGES597-599
http://scigraph.springernature.com/pub.10.1038/319597a0
DOIhttp://dx.doi.org/10.1038/319597a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1026526318
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/2418367
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Physiology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caffeine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calcium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Electric Conductivity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Guinea Pigs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Heart",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "In Vitro Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ion Channels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kinetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Potentials",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sodium",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Institut f\u00fcr Zellphysiologie, Ruhr-Universit\u00e4t Bochum, Postfach 102148, D-4630, Bochum, FRG",
"id": "http://www.grid.ac/institutes/grid.5570.7",
"name": [
"Institut f\u00fcr Zellphysiologie, Ruhr-Universit\u00e4t Bochum, Postfach 102148, D-4630, Bochum, FRG"
],
"type": "Organization"
},
"familyName": "Mechmann",
"givenName": "S.",
"id": "sg:person.01241114355.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241114355.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Zellphysiologie, Ruhr-Universit\u00e4t Bochum, Postfach 102148, D-4630, Bochum, FRG",
"id": "http://www.grid.ac/institutes/grid.5570.7",
"name": [
"Institut f\u00fcr Zellphysiologie, Ruhr-Universit\u00e4t Bochum, Postfach 102148, D-4630, Bochum, FRG"
],
"type": "Organization"
},
"familyName": "Pott",
"givenName": "L.",
"id": "sg:person.0710551536.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710551536.08"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/978-1-4684-4082-9_82",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051526909",
"https://doi.org/10.1007/978-1-4684-4082-9_82"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/301248a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028082642",
"https://doi.org/10.1038/301248a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00656997",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014806333",
"https://doi.org/10.1007/bf00656997"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4615-7858-1_7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014083884",
"https://doi.org/10.1007/978-1-4615-7858-1_7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/294752a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018721316",
"https://doi.org/10.1038/294752a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1986-02",
"datePublishedReg": "1986-02-01",
"description": "In cardiac muscle the exchange of intracellular Ca2+ for extracellular Na+ is an important transport mechanism for regulation of the intracellular free Ca2+ concentration ([Ca]i) and hence the contractile strength of the heart (ref. 1 ; for reviews see refs 2\u20134). Due to its stoichiometry of \u22653:l Na+/Ca2+ (refs 3,5), Na-Ca exchange is supposed to generate a current across the cell membrane. It is thought that such a current may contribute to cardiac action potential and physiological or pathological pacemaker activity6,7. Although the occurrence of Na-Ca exchange is well documented, a membrane current generated by this transport has not been identified unequivocally. Previous attempts to detect such a current-in multicellular preparations, for example, by measuring small current differences after varying the extracellular ionic composition8, although providing evidence, did not rule out other possible interpretations. Here we demonstrate that a transient rise in [Ca]i caused by release of Ca from sarcoplasmic reticulum (SR) generates a membrane current in cardiac myocytes. The dependence of this current on the transmembrane gradients for Na+ and Ca2+ and on membrane potential meets the criteria for a current produced by electrogenic Na-Ca exchange. Cyclic activation of this current by release of Ca from the SR can cause maintained spontaneous activity, suggesting that Na-Ca exchange contributes to certain forms of cardiac pacemaking.",
"genre": "article",
"id": "sg:pub.10.1038/319597a0",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6054",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "319"
}
],
"keywords": [
"cardiac myocytes",
"cell membrane",
"release of Ca",
"transmembrane gradient",
"sarcoplasmic reticulum",
"intracellular free Ca2",
"intracellular Ca2",
"cyclic activation",
"cardiac pacemaking",
"membrane",
"cardiac muscle",
"free Ca2",
"Ca2",
"cardiac action potential",
"exchange contributes",
"reticulum",
"regulation",
"transport mechanism",
"myocytes",
"membrane currents",
"activation",
"Na-Ca exchange",
"transient rise",
"release",
"identification",
"exchange",
"Ca",
"contributes",
"mechanism",
"stoichiometry",
"pacemaking",
"previous attempts",
"activity",
"transport",
"certain forms",
"gradient",
"muscle",
"contractile strength",
"evidence",
"occurrence",
"potential",
"single cardiac myocytes",
"form",
"action potentials",
"heart",
"concentration",
"differences",
"rise",
"electrogenic Na-Ca exchange",
"multicellular preparations",
"example",
"possible interpretations",
"preparation",
"attempt",
"current difference",
"pacemaker",
"current",
"interpretation",
"dependence",
"spontaneous activity",
"strength",
"criteria",
"important transport mechanism"
],
"name": "Identification of Na-Ca exchange current in single cardiac myocytes",
"pagination": "597-599",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1026526318"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/319597a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"2418367"
]
}
],
"sameAs": [
"https://doi.org/10.1038/319597a0",
"https://app.dimensions.ai/details/publication/pub.1026526318"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T21:59",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_192.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/319597a0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/319597a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/319597a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/319597a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/319597a0'
This table displays all metadata directly associated to this object as RDF triples.
196 TRIPLES
22 PREDICATES
106 URIs
93 LITERALS
18 BLANK NODES