A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-02

AUTHORS

Carl-Henrik Heldin, Ann Johnsson, Suzanne Wennergren, Christer Wernstedt, Christer Betsholtz, Bengt Westermark

ABSTRACT

Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGF seems to be important for its biological effects, as reduction irreversibly inactivates the factor; it is not known, however, whether PDGF exists as a heterodimer or as a mixture of homodimers. Amino-acid sequence analysis has revealed that the A- and B-chains of human PDGF are related to each other, and that the B-chain is almost identical to part of the v-sis gene product of simian sarcoma virus (SSV)2–5. There is experimental evidence that a PDGF-like protein is indeed operational in SSV-induced transformation6–12 and the biologically active v-sis product is probably structurally similar to a putative dimer of PDGF B-chains13. PDGF-like growth factors and/or a 4.2-kilobase (kb) c-sis transcript are present in several transformed mammalian cell lines7,14–24 and in certain nontrans-formed cells25–30; cloned c-sis complementary DNA from human T cells transformed with human T-lymphotropic virus (HTLV)24,31 or from human endothelial cells32 contains the coding sequence for a putative PDGF B-chain precursor, but apparently lacks PDGF A-chain sequences. We have previously partially purified and characterized a PDGF-like growth factor from U-2 OS cells (osteosarcoma-derived growth factor, ODGF) and shown that this factor has structural, functional and immunological characteristics in common with PDGF14. We describe here a procedure for the preparation of homogeneous ODGF, and provide evidence that this factor, which binds to the PDGF receptor, has a structure similar to a homodimer of PDGF A-chains. More... »

PAGES

511-514

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/319511a0

DOI

http://dx.doi.org/10.1038/319511a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031828668

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3456080


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Polyacrylamide Gel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet-Derived Growth Factor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heldin", 
        "givenName": "Carl-Henrik", 
        "id": "sg:person.0754771316.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754771316.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnsson", 
        "givenName": "Ann", 
        "id": "sg:person.01153607337.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153607337.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wennergren", 
        "givenName": "Suzanne", 
        "id": "sg:person.01076634715.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076634715.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wernstedt", 
        "givenName": "Christer", 
        "id": "sg:person.01233541357.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233541357.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.412354.5", 
          "name": [
            "Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Betsholtz", 
        "givenName": "Christer", 
        "id": "sg:person.01273525553.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273525553.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.412354.5", 
          "name": [
            "Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westermark", 
        "givenName": "Bengt", 
        "id": "sg:person.01336151137.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336151137.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/316748a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042239674", 
          "https://doi.org/10.1038/316748a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/311669a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005106957", 
          "https://doi.org/10.1038/311669a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/305605a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043416987", 
          "https://doi.org/10.1038/305605a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/304035a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007830435", 
          "https://doi.org/10.1038/304035a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/317438a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015576546", 
          "https://doi.org/10.1038/317438a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/194495a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006221676", 
          "https://doi.org/10.1038/194495a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/295116a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047870747", 
          "https://doi.org/10.1038/295116a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1986-02", 
    "datePublishedReg": "1986-02-01", 
    "description": "Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGF seems to be important for its biological effects, as reduction irreversibly inactivates the factor; it is not known, however, whether PDGF exists as a heterodimer or as a mixture of homodimers. Amino-acid sequence analysis has revealed that the A- and B-chains of human PDGF are related to each other, and that the B-chain is almost identical to part of the v-sis gene product of simian sarcoma virus (SSV)2\u20135. There is experimental evidence that a PDGF-like protein is indeed operational in SSV-induced transformation6\u201312 and the biologically active v-sis product is probably structurally similar to a putative dimer of PDGF B-chains13. PDGF-like growth factors and/or a 4.2-kilobase (kb) c-sis transcript are present in several transformed mammalian cell lines7,14\u201324 and in certain nontrans-formed cells25\u201330; cloned c-sis complementary DNA from human T cells transformed with human T-lymphotropic virus (HTLV)24,31 or from human endothelial cells32 contains the coding sequence for a putative PDGF B-chain precursor, but apparently lacks PDGF A-chain sequences. We have previously partially purified and characterized a PDGF-like growth factor from U-2 OS cells (osteosarcoma-derived growth factor, ODGF) and shown that this factor has structural, functional and immunological characteristics in common with PDGF14. We describe here a procedure for the preparation of homogeneous ODGF, and provide evidence that this factor, which binds to the PDGF receptor, has a structure similar to a homodimer of PDGF A-chains.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/319511a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6053", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "319"
      }
    ], 
    "keywords": [
      "platelet-derived growth factor", 
      "PDGF-like growth factor", 
      "PDGF A-chain", 
      "v-sis gene product", 
      "growth factor", 
      "B chain precursor", 
      "amino acid sequence analysis", 
      "B chain", 
      "A-chain sequence", 
      "A-chain", 
      "PDGF-like protein", 
      "relative molecular mass", 
      "mixture of homodimers", 
      "simian sarcoma virus", 
      "human platelet-derived growth factor", 
      "mammalian cells", 
      "v-sis product", 
      "gene products", 
      "human osteosarcoma cell lines", 
      "sequence analysis", 
      "putative dimer", 
      "osteosarcoma cell lines", 
      "molecular mass", 
      "complementary DNA", 
      "PDGF receptor", 
      "sarcoma virus", 
      "homodimer", 
      "subunit chains", 
      "human T cells", 
      "fresh human platelets", 
      "cell lines", 
      "c-sis transcript", 
      "protein", 
      "human platelets", 
      "biological effects", 
      "cells", 
      "OS cells", 
      "sequence", 
      "similar size", 
      "human T-lymphotropic virus", 
      "dimer structure", 
      "T-lymphotropic virus", 
      "heterodimers", 
      "transcripts", 
      "DNA", 
      "virus", 
      "T cells", 
      "experimental evidence", 
      "nontrans", 
      "immunological characteristics", 
      "receptors", 
      "dimers", 
      "factors", 
      "evidence", 
      "lines", 
      "structure", 
      "precursors", 
      "products", 
      "platelets", 
      "chain", 
      "SSV", 
      "analysis", 
      "size", 
      "mass", 
      "part", 
      "effect", 
      "reduction", 
      "procedure", 
      "preparation", 
      "mixture", 
      "characteristics"
    ], 
    "name": "A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains", 
    "pagination": "511-514", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031828668"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/319511a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3456080"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/319511a0", 
      "https://app.dimensions.ai/details/publication/pub.1031828668"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_184.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/319511a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/319511a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/319511a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/319511a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/319511a0'


 

This table displays all metadata directly associated to this object as RDF triples.

226 TRIPLES      21 PREDICATES      111 URIs      96 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/319511a0 schema:about N2f625003014d42659f98db38d4f5a0ca
2 N38833c57577546b1999cc46eb4781c43
3 N4cf695c341e14023bbbaffc68ac82101
4 N6b17804ae6b5495bbde7046cbb527727
5 N7f2b40e1f6654ad68397ffc323f1a223
6 Nc3179c23ca604528b56ca4fdd2581c46
7 Nf877334a1121416bbd01a1cbb88f9d9c
8 anzsrc-for:06
9 anzsrc-for:0601
10 schema:author Nf1f3974b65c240948d1deef062ca454b
11 schema:citation sg:pub.10.1038/194495a0
12 sg:pub.10.1038/295116a0
13 sg:pub.10.1038/304035a0
14 sg:pub.10.1038/305605a0
15 sg:pub.10.1038/311669a0
16 sg:pub.10.1038/316748a0
17 sg:pub.10.1038/317438a0
18 schema:datePublished 1986-02
19 schema:datePublishedReg 1986-02-01
20 schema:description Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGF seems to be important for its biological effects, as reduction irreversibly inactivates the factor; it is not known, however, whether PDGF exists as a heterodimer or as a mixture of homodimers. Amino-acid sequence analysis has revealed that the A- and B-chains of human PDGF are related to each other, and that the B-chain is almost identical to part of the v-sis gene product of simian sarcoma virus (SSV)2–5. There is experimental evidence that a PDGF-like protein is indeed operational in SSV-induced transformation6–12 and the biologically active v-sis product is probably structurally similar to a putative dimer of PDGF B-chains13. PDGF-like growth factors and/or a 4.2-kilobase (kb) c-sis transcript are present in several transformed mammalian cell lines7,14–24 and in certain nontrans-formed cells25–30; cloned c-sis complementary DNA from human T cells transformed with human T-lymphotropic virus (HTLV)24,31 or from human endothelial cells32 contains the coding sequence for a putative PDGF B-chain precursor, but apparently lacks PDGF A-chain sequences. We have previously partially purified and characterized a PDGF-like growth factor from U-2 OS cells (osteosarcoma-derived growth factor, ODGF) and shown that this factor has structural, functional and immunological characteristics in common with PDGF14. We describe here a procedure for the preparation of homogeneous ODGF, and provide evidence that this factor, which binds to the PDGF receptor, has a structure similar to a homodimer of PDGF A-chains.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N4fbe41a108ff42b98ed12caacf9c011e
24 Nc1016c9b51a24dbbad5b282f67006bb4
25 sg:journal.1018957
26 schema:keywords A-chain
27 A-chain sequence
28 B chain
29 B chain precursor
30 DNA
31 OS cells
32 PDGF A-chain
33 PDGF receptor
34 PDGF-like growth factor
35 PDGF-like protein
36 SSV
37 T cells
38 T-lymphotropic virus
39 amino acid sequence analysis
40 analysis
41 biological effects
42 c-sis transcript
43 cell lines
44 cells
45 chain
46 characteristics
47 complementary DNA
48 dimer structure
49 dimers
50 effect
51 evidence
52 experimental evidence
53 factors
54 fresh human platelets
55 gene products
56 growth factor
57 heterodimers
58 homodimer
59 human T cells
60 human T-lymphotropic virus
61 human osteosarcoma cell lines
62 human platelet-derived growth factor
63 human platelets
64 immunological characteristics
65 lines
66 mammalian cells
67 mass
68 mixture
69 mixture of homodimers
70 molecular mass
71 nontrans
72 osteosarcoma cell lines
73 part
74 platelet-derived growth factor
75 platelets
76 precursors
77 preparation
78 procedure
79 products
80 protein
81 putative dimer
82 receptors
83 reduction
84 relative molecular mass
85 sarcoma virus
86 sequence
87 sequence analysis
88 simian sarcoma virus
89 similar size
90 size
91 structure
92 subunit chains
93 transcripts
94 v-sis gene product
95 v-sis product
96 virus
97 schema:name A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains
98 schema:pagination 511-514
99 schema:productId N6195da6c0d524673a013d0ab95c38e00
100 N7bad1bd196034282b8e33a230d421e78
101 N9a60a8a5a4e54062a48c9294d32c0f81
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031828668
103 https://doi.org/10.1038/319511a0
104 schema:sdDatePublished 2022-10-01T06:27
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N653213ce6d454e5a8d5c009d950c06f7
107 schema:url https://doi.org/10.1038/319511a0
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N0738f791e1604595ba0697770419f02b rdf:first sg:person.01233541357.47
112 rdf:rest N46b7af6975564c59a209050132a38637
113 N2f625003014d42659f98db38d4f5a0ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cell Line
115 rdf:type schema:DefinedTerm
116 N38833c57577546b1999cc46eb4781c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Growth Substances
118 rdf:type schema:DefinedTerm
119 N46b7af6975564c59a209050132a38637 rdf:first sg:person.01273525553.31
120 rdf:rest Ndd6b4d0b89d74e80806fae22fbce1ef5
121 N4cf695c341e14023bbbaffc68ac82101 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N4fbe41a108ff42b98ed12caacf9c011e schema:volumeNumber 319
125 rdf:type schema:PublicationVolume
126 N6195da6c0d524673a013d0ab95c38e00 schema:name dimensions_id
127 schema:value pub.1031828668
128 rdf:type schema:PropertyValue
129 N653213ce6d454e5a8d5c009d950c06f7 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 N6b17804ae6b5495bbde7046cbb527727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Electrophoresis, Polyacrylamide Gel
133 rdf:type schema:DefinedTerm
134 N760f43bdbfc8411884cb43aa8bc2f5e9 rdf:first sg:person.01076634715.85
135 rdf:rest N0738f791e1604595ba0697770419f02b
136 N7bad1bd196034282b8e33a230d421e78 schema:name pubmed_id
137 schema:value 3456080
138 rdf:type schema:PropertyValue
139 N7f2b40e1f6654ad68397ffc323f1a223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Osteosarcoma
141 rdf:type schema:DefinedTerm
142 N9a60a8a5a4e54062a48c9294d32c0f81 schema:name doi
143 schema:value 10.1038/319511a0
144 rdf:type schema:PropertyValue
145 Na1e7a1f07b6e497a8e34063e65462ec5 rdf:first sg:person.01153607337.13
146 rdf:rest N760f43bdbfc8411884cb43aa8bc2f5e9
147 Nc1016c9b51a24dbbad5b282f67006bb4 schema:issueNumber 6053
148 rdf:type schema:PublicationIssue
149 Nc3179c23ca604528b56ca4fdd2581c46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Macromolecular Substances
151 rdf:type schema:DefinedTerm
152 Ndd6b4d0b89d74e80806fae22fbce1ef5 rdf:first sg:person.01336151137.55
153 rdf:rest rdf:nil
154 Nf1f3974b65c240948d1deef062ca454b rdf:first sg:person.0754771316.18
155 rdf:rest Na1e7a1f07b6e497a8e34063e65462ec5
156 Nf877334a1121416bbd01a1cbb88f9d9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Platelet-Derived Growth Factor
158 rdf:type schema:DefinedTerm
159 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
160 schema:name Biological Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
163 schema:name Biochemistry and Cell Biology
164 rdf:type schema:DefinedTerm
165 sg:journal.1018957 schema:issn 0028-0836
166 1476-4687
167 schema:name Nature
168 schema:publisher Springer Nature
169 rdf:type schema:Periodical
170 sg:person.01076634715.85 schema:affiliation grid-institutes:None
171 schema:familyName Wennergren
172 schema:givenName Suzanne
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076634715.85
174 rdf:type schema:Person
175 sg:person.01153607337.13 schema:affiliation grid-institutes:None
176 schema:familyName Johnsson
177 schema:givenName Ann
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153607337.13
179 rdf:type schema:Person
180 sg:person.01233541357.47 schema:affiliation grid-institutes:None
181 schema:familyName Wernstedt
182 schema:givenName Christer
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233541357.47
184 rdf:type schema:Person
185 sg:person.01273525553.31 schema:affiliation grid-institutes:grid.412354.5
186 schema:familyName Betsholtz
187 schema:givenName Christer
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273525553.31
189 rdf:type schema:Person
190 sg:person.01336151137.55 schema:affiliation grid-institutes:grid.412354.5
191 schema:familyName Westermark
192 schema:givenName Bengt
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336151137.55
194 rdf:type schema:Person
195 sg:person.0754771316.18 schema:affiliation grid-institutes:None
196 schema:familyName Heldin
197 schema:givenName Carl-Henrik
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754771316.18
199 rdf:type schema:Person
200 sg:pub.10.1038/194495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006221676
201 https://doi.org/10.1038/194495a0
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/295116a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047870747
204 https://doi.org/10.1038/295116a0
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/304035a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007830435
207 https://doi.org/10.1038/304035a0
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/305605a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043416987
210 https://doi.org/10.1038/305605a0
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/311669a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005106957
213 https://doi.org/10.1038/311669a0
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/316748a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042239674
216 https://doi.org/10.1038/316748a0
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/317438a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015576546
219 https://doi.org/10.1038/317438a0
220 rdf:type schema:CreativeWork
221 grid-institutes:None schema:alternateName Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden
222 schema:name Department of Medical and Physiological Chemistry, Biomedicum, Box 575, S-751 23, Uppsala, Sweden
223 rdf:type schema:Organization
224 grid-institutes:grid.412354.5 schema:alternateName Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden
225 schema:name Department of Pathology, University Hospital, S-751 85, Uppsala, Sweden
226 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...