fgr proto-oncogene mRNA induced in B lymphocytes by Epstein–Barr virus infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1986-01

AUTHORS

Marc S. C. Cheah, Timothy J. Ley, Steven R. Tronick, Keith C. Robbins

ABSTRACT

Several acute transforming retroviruses encode tyrosine-specific protein kinases which possess structural and functional relationships to cell-surface receptors for certain growth factors1,2. One such tyrosine kinase is encoded by the onc gene, v-fgr, of Gardner-Rasheed feline sarcoma virus (GR-FeSV)3–6. Recently, we have isolated and characterized the human gene, c-fgr, corresponding to the viral onc sequence and have shown that c-fgr is a unique gene located on the short arm of chromosome 1 (ref. 7). Here we report that certain lymphomas (but not sarcomas or carcinomas) express fgr-related messenger RNA. This transcript is detected in Burkitt's lymphoma cell lines naturally infected with Epstein-Barr virus (EBV), but not in EBV-negative Burkitt's lymphoma cells. Normal umbilical cord or peripheral blood lymphocyte lines established in vitro by EBV infection also contain detectable c-fgr mRNA. Moreover, a 50-fold increase of the steady-state c-fgr mRNA concentration is observed when uninfected Burkitt's lymphoma cell lines are deliberately infected with EBV. These findings demonstrate for the first time the induction of a proto-oncogene in response to infection by a DNA tumour virus. More... »

PAGES

238-240

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/319238a0

DOI

http://dx.doi.org/10.1038/319238a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042866954

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3003578


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