Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-01

AUTHORS

Tadashi Yamamoto, Shuntaro Ikawa, Tetsu Akiyama, Kentaro Semba, Nobuo Nomura, Nobuyuki Miyajima, Toshiyuki Saito, Kumao Toyoshima

ABSTRACT

A novel v-erb-B-related gene, c-erb-B-2, which has been identified in the human genome, maps to human chromosome 17 at q21 (ref. 40), and seems to encode a polypeptide with a kinase domain that is highly homologous with, but distinct from, that of the epidermal growth factor (EGF) receptor. The c-erb-B-2 gene is conserved in vertebrates and it has been suggested that the neu gene, detected in a series of rat neuro/glioblastomas, is, in fact, the rat c-erb-B-2 gene. Amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process. To determine the nature of the c-erb-B-2 protein, we have now molecularly cloned complementary DNA for c-erb-B-2 messenger RNA prepared from MKN-7 cells. Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product. As a consequence of chromosomal aberration in MKN-7 cells, a 4.6-kilobase (kb) normal transcript and a truncated 2.3-kb transcript of c-erb-B-2 are synthesized at elevated levels. The latter transcript presumably encodes only the extracellular domain of the putative receptor. More... »

PAGES

230-234

Journal

TITLE

Nature

ISSUE

6050

VOLUME

319

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    http://scigraph.springernature.com/pub.10.1038/319230a0

    DOI

    http://dx.doi.org/10.1038/319230a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021830143

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3003577


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/319230a0'

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    RDF/XML is a standard XML format for linked data.

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