A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-11

AUTHORS

Robert G. Knowlton, Odile Cohen-Haguenauer, Nguyen Van Cong, Jean Frézal, Valerie A. Brown, David Barker, Jeffrey C. Braman, James W. Schumm, Lap-Chee Tsui, Manuel Buchwald, Helen Donis-Keller

ABSTRACT

Although cystic fibrosis (CF) is among the most common inherited diseases in Caucasian populations, the basic biochemical defect is not yet known. CF is inherited as an autosomal recessive trait apparently due to mutations in a single gene, whence the efforts made to identify the genetic locus responsible by linkage studies. Two markers have recently been identified that are genetically linked to CF: one is a genetic variation in serum level of activity of the enzyme paraoxonase, and the other is a restriction fragment length polymorphism (RFLP) identified with a randomly isolated DNA probe. We report here that the genetic locus DOCRI-917 defined by the cloned DNA probe is located on chromosome 7. More... »

PAGES

380-382

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/318380a0

DOI

http://dx.doi.org/10.1038/318380a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008813443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2999611


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