Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-09

AUTHORS

J. Scott, J. Cowell, M. E. Robertson, L. M. Priestley, R. Wadey, B. Hopkins, J. Pritchard, G. I. Bell, L. B. Rall, C. F. Graham, T. J. Knott

ABSTRACT

Wilms' tumour (nephroblastoma) is an embryonal neoplasm occurring in hereditary and spontaneous forms. Both types show rearrangements of the short arm of chromosome 11. The germ line of children with the rare inherited triad of aniridia, genitourinary abnormality and mental retardation carry a chromosome 11 that has a deletion in its short arm (band 11p13) and these children are at increased risk of developing Wilms' tumour1,2. Neonates with the Beckwith–Wiedemann syndrome, in which there may be duplication of the 11p13–11p15 region, are similarly predisposed3. In the spontaneous form of the tumour a deletion of the Hp14 band in tumour cells, but not in normal cells, has been reported4, and the development of homozygosity for recessive mutations in the 11p region is implicated in the aetiology of Wilms' tumour5–8. In view of these chromosomal rearrangements and because Wilms' tumour is historically indistinguishable from the early stages of kidney development9, we have now examined the expression of genes localized to 11p in Wilms' tumour and human embryonic tissue. In 12 sporadic tumours examined, the expression of the gene coding for insulin-like growth factor-II (IGF-II), localized to the 11p15 region, was markedly increased relative to adult tissues, but was comparable to the level of expression in several fetal tissues including kidney, liver, adrenals and striated muscle. This may reflect the stage of tumour differentiation, but could also contribute to the malignant process, as IGF-II is an embryonal mitogen10–13. More... »

PAGES

260-262

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/317260a0

DOI

http://dx.doi.org/10.1038/317260a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000393669

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2995818


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wilms Tumor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scott", 
        "givenName": "J.", 
        "id": "sg:person.0762127452.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762127452.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cowell", 
        "givenName": "J.", 
        "id": "sg:person.01273011766.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273011766.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robertson", 
        "givenName": "M. E.", 
        "id": "sg:person.0636453211.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636453211.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Priestley", 
        "givenName": "L. M.", 
        "id": "sg:person.01164561443.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164561443.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wadey", 
        "givenName": "R.", 
        "id": "sg:person.01151532540.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151532540.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Zoology, University of Oxford, South Parks Rd, OX1 3PS, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Department of Zoology, University of Oxford, South Parks Rd, OX1 3PS, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hopkins", 
        "givenName": "B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pritchard", 
        "givenName": "J.", 
        "id": "sg:person.0720651546.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720651546.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton St, 94608, Emeryville, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton St, 94608, Emeryville, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bell", 
        "givenName": "G. I.", 
        "id": "sg:person.016340630557.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016340630557.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton St, 94608, Emeryville, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton St, 94608, Emeryville, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rall", 
        "givenName": "L. B.", 
        "id": "sg:person.065774441.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065774441.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Zoology, University of Oxford, South Parks Rd, OX1 3PS, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Department of Zoology, University of Oxford, South Parks Rd, OX1 3PS, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graham", 
        "givenName": "C. F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knott", 
        "givenName": "T. J.", 
        "id": "sg:person.0745635377.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745635377.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/295345a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021189874", 
          "https://doi.org/10.1038/295345a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/310775a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045169743", 
          "https://doi.org/10.1038/310775a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/302150a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006473016", 
          "https://doi.org/10.1038/302150a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309170a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013017501", 
          "https://doi.org/10.1038/309170a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309172a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006555130", 
          "https://doi.org/10.1038/309172a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309176a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037654366", 
          "https://doi.org/10.1038/309176a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00287635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021910495", 
          "https://doi.org/10.1007/bf00287635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/310784a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040239583", 
          "https://doi.org/10.1038/310784a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309174a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042842190", 
          "https://doi.org/10.1038/309174a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316330a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039175745", 
          "https://doi.org/10.1038/316330a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313228a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014681583", 
          "https://doi.org/10.1038/313228a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/305638a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017555198", 
          "https://doi.org/10.1038/305638a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/305641a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034290871", 
          "https://doi.org/10.1038/305641a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/302033a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031650611", 
          "https://doi.org/10.1038/302033a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1985-09", 
    "datePublishedReg": "1985-09-01", 
    "description": "Wilms' tumour (nephroblastoma) is an embryonal neoplasm occurring in hereditary and spontaneous forms. Both types show rearrangements of the short arm of chromosome 11. The germ line of children with the rare inherited triad of aniridia, genitourinary abnormality and mental retardation carry a chromosome 11 that has a deletion in its short arm (band 11p13) and these children are at increased risk of developing Wilms' tumour1,2. Neonates with the Beckwith\u2013Wiedemann syndrome, in which there may be duplication of the 11p13\u201311p15 region, are similarly predisposed3. In the spontaneous form of the tumour a deletion of the Hp14 band in tumour cells, but not in normal cells, has been reported4, and the development of homozygosity for recessive mutations in the 11p region is implicated in the aetiology of Wilms' tumour5\u20138. In view of these chromosomal rearrangements and because Wilms' tumour is historically indistinguishable from the early stages of kidney development9, we have now examined the expression of genes localized to 11p in Wilms' tumour and human embryonic tissue. In 12 sporadic tumours examined, the expression of the gene coding for insulin-like growth factor-II (IGF-II), localized to the 11p15 region, was markedly increased relative to adult tissues, but was comparable to the level of expression in several fetal tissues including kidney, liver, adrenals and striated muscle. This may reflect the stage of tumour differentiation, but could also contribute to the malignant process, as IGF-II is an embryonal mitogen10\u201313.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/317260a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6034", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "317"
      }
    ], 
    "keywords": [
      "insulin-like growth factor", 
      "Wilms' tumor", 
      "growth factor", 
      "spontaneous form", 
      "Beckwith-Wiedemann syndrome", 
      "embryonal neoplasm", 
      "tumor differentiation", 
      "malignant process", 
      "tumors", 
      "genitourinary abnormalities", 
      "fetal tissues", 
      "tumor cells", 
      "sporadic tumors", 
      "level of expression", 
      "human embryonic tissues", 
      "mental retardation", 
      "embryonic tissues", 
      "Wilms", 
      "normal cells", 
      "tissue", 
      "expression of genes", 
      "development of homozygosity", 
      "chromosome 11", 
      "children", 
      "short arm", 
      "expression", 
      "early stages", 
      "adult tissues", 
      "gene expression", 
      "neonates", 
      "cells", 
      "IGF", 
      "arm", 
      "adrenals", 
      "neoplasms", 
      "syndrome", 
      "etiology", 
      "kidney", 
      "abnormalities", 
      "recessive mutations", 
      "liver", 
      "muscle", 
      "factors", 
      "aniridia", 
      "risk", 
      "germ line", 
      "deletion", 
      "genes", 
      "retardation", 
      "homozygosity", 
      "stage", 
      "chromosomal rearrangements", 
      "mutations", 
      "differentiation", 
      "triad", 
      "levels", 
      "region", 
      "rearrangement", 
      "development", 
      "lines", 
      "form", 
      "types", 
      "duplication", 
      "view", 
      "reported4", 
      "process", 
      "band", 
      "triad of aniridia", 
      "predisposed3", 
      "Hp14 band", 
      "Wilms' tumour5", 
      "' tumour5", 
      "kidney development9", 
      "development9", 
      "embryonal mitogen10", 
      "mitogen10"
    ], 
    "name": "Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues", 
    "pagination": "260-262", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000393669"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/317260a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2995818"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/317260a0", 
      "https://app.dimensions.ai/details/publication/pub.1000393669"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_193.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/317260a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/317260a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/317260a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/317260a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/317260a0'


 

This table displays all metadata directly associated to this object as RDF triples.

327 TRIPLES      22 PREDICATES      131 URIs      107 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/317260a0 schema:about N020fb08359384a78baa020ede98b12ac
2 N0561b1a77431409b9c7f06390c68876b
3 N260cb45525df43ee8dc098c62c56dd19
4 N3f861c600585411eaaa399009540fb75
5 N4174a115d6b54f1fb8f9946624c488e6
6 N628fea4d044142a6a744ebaf39aff927
7 N64ef704a37954111895718c6c2b36052
8 N8be366931ab14da088c1cde7f34b2ad3
9 N90592f6e00c44ab78bd3581c3ce3f55c
10 Nb41a29bdd0b749a1b291a0f6a26de848
11 Nc0970603e0a04c22bb39ea4aa3c0bed6
12 Nfe05878652364967aa7f476657e1471d
13 anzsrc-for:06
14 anzsrc-for:0604
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nefbe9c1de1ed444d8e1fc7057a40f813
18 schema:citation sg:pub.10.1007/bf00287635
19 sg:pub.10.1038/295345a0
20 sg:pub.10.1038/302033a0
21 sg:pub.10.1038/302150a0
22 sg:pub.10.1038/305638a0
23 sg:pub.10.1038/305641a0
24 sg:pub.10.1038/309170a0
25 sg:pub.10.1038/309172a0
26 sg:pub.10.1038/309174a0
27 sg:pub.10.1038/309176a0
28 sg:pub.10.1038/310775a0
29 sg:pub.10.1038/310784a0
30 sg:pub.10.1038/313228a0
31 sg:pub.10.1038/316330a0
32 schema:datePublished 1985-09
33 schema:datePublishedReg 1985-09-01
34 schema:description Wilms' tumour (nephroblastoma) is an embryonal neoplasm occurring in hereditary and spontaneous forms. Both types show rearrangements of the short arm of chromosome 11. The germ line of children with the rare inherited triad of aniridia, genitourinary abnormality and mental retardation carry a chromosome 11 that has a deletion in its short arm (band 11p13) and these children are at increased risk of developing Wilms' tumour1,2. Neonates with the Beckwith–Wiedemann syndrome, in which there may be duplication of the 11p13–11p15 region, are similarly predisposed3. In the spontaneous form of the tumour a deletion of the Hp14 band in tumour cells, but not in normal cells, has been reported4, and the development of homozygosity for recessive mutations in the 11p region is implicated in the aetiology of Wilms' tumour5–8. In view of these chromosomal rearrangements and because Wilms' tumour is historically indistinguishable from the early stages of kidney development9, we have now examined the expression of genes localized to 11p in Wilms' tumour and human embryonic tissue. In 12 sporadic tumours examined, the expression of the gene coding for insulin-like growth factor-II (IGF-II), localized to the 11p15 region, was markedly increased relative to adult tissues, but was comparable to the level of expression in several fetal tissues including kidney, liver, adrenals and striated muscle. This may reflect the stage of tumour differentiation, but could also contribute to the malignant process, as IGF-II is an embryonal mitogen10–13.
35 schema:genre article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N36427ca5078e4cafb486c2dd52e26fdd
39 Nc78063d94eea4fd882a6bf4821ede042
40 sg:journal.1018957
41 schema:keywords ' tumour5
42 Beckwith-Wiedemann syndrome
43 Hp14 band
44 IGF
45 Wilms
46 Wilms' tumor
47 Wilms' tumour5
48 abnormalities
49 adrenals
50 adult tissues
51 aniridia
52 arm
53 band
54 cells
55 children
56 chromosomal rearrangements
57 chromosome 11
58 deletion
59 development
60 development of homozygosity
61 development9
62 differentiation
63 duplication
64 early stages
65 embryonal mitogen10
66 embryonal neoplasm
67 embryonic tissues
68 etiology
69 expression
70 expression of genes
71 factors
72 fetal tissues
73 form
74 gene expression
75 genes
76 genitourinary abnormalities
77 germ line
78 growth factor
79 homozygosity
80 human embryonic tissues
81 insulin-like growth factor
82 kidney
83 kidney development9
84 level of expression
85 levels
86 lines
87 liver
88 malignant process
89 mental retardation
90 mitogen10
91 muscle
92 mutations
93 neonates
94 neoplasms
95 normal cells
96 predisposed3
97 process
98 rearrangement
99 recessive mutations
100 region
101 reported4
102 retardation
103 risk
104 short arm
105 spontaneous form
106 sporadic tumors
107 stage
108 syndrome
109 tissue
110 triad
111 triad of aniridia
112 tumor cells
113 tumor differentiation
114 tumors
115 types
116 view
117 schema:name Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues
118 schema:pagination 260-262
119 schema:productId N334a58a938884ba88addeaa29f7c0420
120 Nc471468eefe24c7f89f7272f62234de5
121 Nc7f64db5ca424e36a775623e93c34775
122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000393669
123 https://doi.org/10.1038/317260a0
124 schema:sdDatePublished 2021-12-01T19:06
125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
126 schema:sdPublisher N5f2e6fb6448c497c9afb9032787407e6
127 schema:url https://doi.org/10.1038/317260a0
128 sgo:license sg:explorer/license/
129 sgo:sdDataset articles
130 rdf:type schema:ScholarlyArticle
131 N020fb08359384a78baa020ede98b12ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Genes
133 rdf:type schema:DefinedTerm
134 N0505291e836749c9ba7feca319b1c64f rdf:first sg:person.065774441.02
135 rdf:rest N5e41b64c9d974981bf430b6a9f80f911
136 N0561b1a77431409b9c7f06390c68876b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name RNA, Messenger
138 rdf:type schema:DefinedTerm
139 N260cb45525df43ee8dc098c62c56dd19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Kidney Neoplasms
141 rdf:type schema:DefinedTerm
142 N26c3697e8c094352a5380cf072bd7209 rdf:first sg:person.0720651546.27
143 rdf:rest N801a3fcb57fb40cba87b2a1758418195
144 N26d611e314cb49d8ab049da1806cd24d rdf:first sg:person.01164561443.54
145 rdf:rest Nc78e3f890d34415a868b39741c0cbb0e
146 N2dde6a2274ba4d8cbc85329e6c1ce01a rdf:first sg:person.0636453211.40
147 rdf:rest N26d611e314cb49d8ab049da1806cd24d
148 N334a58a938884ba88addeaa29f7c0420 schema:name dimensions_id
149 schema:value pub.1000393669
150 rdf:type schema:PropertyValue
151 N36427ca5078e4cafb486c2dd52e26fdd schema:issueNumber 6034
152 rdf:type schema:PublicationIssue
153 N3f861c600585411eaaa399009540fb75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Transcription, Genetic
155 rdf:type schema:DefinedTerm
156 N40a071f0949e4fd28b9a2197c63b9034 rdf:first sg:person.0745635377.00
157 rdf:rest rdf:nil
158 N4174a115d6b54f1fb8f9946624c488e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Kidney
160 rdf:type schema:DefinedTerm
161 N55c87f719e144385a3483eaacd4ae0c3 schema:affiliation grid-institutes:grid.4991.5
162 schema:familyName Graham
163 schema:givenName C. F.
164 rdf:type schema:Person
165 N5e41b64c9d974981bf430b6a9f80f911 rdf:first N55c87f719e144385a3483eaacd4ae0c3
166 rdf:rest N40a071f0949e4fd28b9a2197c63b9034
167 N5f2e6fb6448c497c9afb9032787407e6 schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N628fea4d044142a6a744ebaf39aff927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Pregnancy
171 rdf:type schema:DefinedTerm
172 N64ef704a37954111895718c6c2b36052 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Wilms Tumor
174 rdf:type schema:DefinedTerm
175 N801a3fcb57fb40cba87b2a1758418195 rdf:first sg:person.016340630557.53
176 rdf:rest N0505291e836749c9ba7feca319b1c64f
177 N8be366931ab14da088c1cde7f34b2ad3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 N90592f6e00c44ab78bd3581c3ce3f55c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Fetus
182 rdf:type schema:DefinedTerm
183 N94439e62d7c648a68da9de02e7331f86 rdf:first Na685e46ef4a748eda1ac157c4dbc354c
184 rdf:rest N26c3697e8c094352a5380cf072bd7209
185 Na685e46ef4a748eda1ac157c4dbc354c schema:affiliation grid-institutes:grid.4991.5
186 schema:familyName Hopkins
187 schema:givenName B.
188 rdf:type schema:Person
189 Nb41a29bdd0b749a1b291a0f6a26de848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 Nc0970603e0a04c22bb39ea4aa3c0bed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Neoplasms
194 rdf:type schema:DefinedTerm
195 Nc471468eefe24c7f89f7272f62234de5 schema:name doi
196 schema:value 10.1038/317260a0
197 rdf:type schema:PropertyValue
198 Nc78063d94eea4fd882a6bf4821ede042 schema:volumeNumber 317
199 rdf:type schema:PublicationVolume
200 Nc78e3f890d34415a868b39741c0cbb0e rdf:first sg:person.01151532540.76
201 rdf:rest N94439e62d7c648a68da9de02e7331f86
202 Nc7f64db5ca424e36a775623e93c34775 schema:name pubmed_id
203 schema:value 2995818
204 rdf:type schema:PropertyValue
205 Ne3a8f338a1974ab3b9fd8d8f298257d8 rdf:first sg:person.01273011766.49
206 rdf:rest N2dde6a2274ba4d8cbc85329e6c1ce01a
207 Nefbe9c1de1ed444d8e1fc7057a40f813 rdf:first sg:person.0762127452.15
208 rdf:rest Ne3a8f338a1974ab3b9fd8d8f298257d8
209 Nfe05878652364967aa7f476657e1471d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Organ Specificity
211 rdf:type schema:DefinedTerm
212 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
213 schema:name Biological Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
216 schema:name Genetics
217 rdf:type schema:DefinedTerm
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
222 schema:name Clinical Sciences
223 rdf:type schema:DefinedTerm
224 sg:journal.1018957 schema:issn 0028-0836
225 1476-4687
226 schema:name Nature
227 schema:publisher Springer Nature
228 rdf:type schema:Periodical
229 sg:person.01151532540.76 schema:affiliation grid-institutes:grid.83440.3b
230 schema:familyName Wadey
231 schema:givenName R.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151532540.76
233 rdf:type schema:Person
234 sg:person.01164561443.54 schema:affiliation grid-institutes:None
235 schema:familyName Priestley
236 schema:givenName L. M.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164561443.54
238 rdf:type schema:Person
239 sg:person.01273011766.49 schema:affiliation grid-institutes:grid.83440.3b
240 schema:familyName Cowell
241 schema:givenName J.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273011766.49
243 rdf:type schema:Person
244 sg:person.016340630557.53 schema:affiliation grid-institutes:grid.418424.f
245 schema:familyName Bell
246 schema:givenName G. I.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016340630557.53
248 rdf:type schema:Person
249 sg:person.0636453211.40 schema:affiliation grid-institutes:None
250 schema:familyName Robertson
251 schema:givenName M. E.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636453211.40
253 rdf:type schema:Person
254 sg:person.065774441.02 schema:affiliation grid-institutes:grid.418424.f
255 schema:familyName Rall
256 schema:givenName L. B.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065774441.02
258 rdf:type schema:Person
259 sg:person.0720651546.27 schema:affiliation grid-institutes:grid.83440.3b
260 schema:familyName Pritchard
261 schema:givenName J.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720651546.27
263 rdf:type schema:Person
264 sg:person.0745635377.00 schema:affiliation grid-institutes:None
265 schema:familyName Knott
266 schema:givenName T. J.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745635377.00
268 rdf:type schema:Person
269 sg:person.0762127452.15 schema:affiliation grid-institutes:None
270 schema:familyName Scott
271 schema:givenName J.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762127452.15
273 rdf:type schema:Person
274 sg:pub.10.1007/bf00287635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021910495
275 https://doi.org/10.1007/bf00287635
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/295345a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021189874
278 https://doi.org/10.1038/295345a0
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/302033a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031650611
281 https://doi.org/10.1038/302033a0
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/302150a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006473016
284 https://doi.org/10.1038/302150a0
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/305638a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017555198
287 https://doi.org/10.1038/305638a0
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/305641a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034290871
290 https://doi.org/10.1038/305641a0
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/309170a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013017501
293 https://doi.org/10.1038/309170a0
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/309172a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006555130
296 https://doi.org/10.1038/309172a0
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/309174a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042842190
299 https://doi.org/10.1038/309174a0
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/309176a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037654366
302 https://doi.org/10.1038/309176a0
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/310775a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045169743
305 https://doi.org/10.1038/310775a0
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/310784a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040239583
308 https://doi.org/10.1038/310784a0
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/313228a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014681583
311 https://doi.org/10.1038/313228a0
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/316330a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039175745
314 https://doi.org/10.1038/316330a0
315 rdf:type schema:CreativeWork
316 grid-institutes:None schema:alternateName Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK
317 schema:name Molecular Medicine Research, MRC Clinical Research Centre, HA1 3UJ, HarrowMiddlesex, UK
318 rdf:type schema:Organization
319 grid-institutes:grid.418424.f schema:alternateName Chiron Corporation, 4560 Horton St, 94608, Emeryville, California, USA
320 schema:name Chiron Corporation, 4560 Horton St, 94608, Emeryville, California, USA
321 rdf:type schema:Organization
322 grid-institutes:grid.4991.5 schema:alternateName Department of Zoology, University of Oxford, South Parks Rd, OX1 3PS, Oxford, UK
323 schema:name Department of Zoology, University of Oxford, South Parks Rd, OX1 3PS, Oxford, UK
324 rdf:type schema:Organization
325 grid-institutes:grid.83440.3b schema:alternateName Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK
326 schema:name Department of Molecular Genetics and Oncology, Institute of Child Health, University of London, Guilford Street, WC1N 1EH, London, UK
327 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...