Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-08

AUTHORS

Yasunobu Yoshikai, Stephen P. Clark, Sheryle Taylor, Uik Sohn, Bonnie I. Wilson, Mark D. Minden, Tak W. Mak

ABSTRACT

An essential property of the immune system is its ability to generate great diversity in antibody and T-cell immune responses. The genetic and molecular mechanisms responsible for the generation of antibody diversity have been investigated during the past several years1,2. The gene for the variable (V) region, which determines antigen specificity, is assembled when one member of each of the dispersed clusters of V gene segments, diversity (D) elements (for heavy chains only) and joining (J) segments are fused by DNA rearrangement1–3. The cloning of the β-chain of the T-cell antigen receptor4,5 revealed that the organization of the β-chain locus, which is similar to that of immunoglobulin genes6–12, is also composed of noncontiguous segments of V7–9, D10,11, J6,9,11 and constant (C) region genes6–12. The structure of the α-chain seems to consist of a V and a C domain connected by a J segment13–16. We report here that the human T-cell receptor α-chain gene consists of a number of noncontiguous V and J gene segments and a C region gene. The V region gene segment is interrupted by a single intron, whereas the C region contains four exons. The J segments, situated 5′ of the C region gene, are dispersed over a distance of at least 35 kilobases (kb). Signal sequences, which are presumably involved in DNA recombination, are found next to the V and J gene segments. More... »

PAGES

837-840

Journal

TITLE

Nature

ISSUE

6031

VOLUME

316

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/316837a0

    DOI

    http://dx.doi.org/10.1038/316837a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024200750

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2993909


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    57 cloning
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    62 diversity
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    67 exons
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    69 generation
    70 genes
    71 great diversity
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    74 introns
    75 kilobases
    76 loci
    77 mechanism
    78 members
    79 molecular mechanisms
    80 noncontiguous segments
    81 number
    82 organization
    83 properties
    84 receptor α chain
    85 recombination
    86 region
    87 region gene segments
    88 region genes
    89 response
    90 segments
    91 sequence
    92 signal sequence
    93 single intron
    94 specificity
    95 structure
    96 system
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