Unusual organization and diversity of T-cell receptor a-chain genes View Full Text


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Article Info

DATE

1985-08

AUTHORS

Adrian C. Hayday, Don J. Diamond, Gary Tanigawa, Joseph S. Heilig, Virginia Folsom, Haruo Saito, Susumu Tonegawa

ABSTRACT

T lymphocytes recognize cell-bound antigens in the molecular context of the self major histocompatibility complex (MHC) gene products through the surface T-cell receptor(s). The minimal component of the T-cell receptor is a heterodimer composed of α and β subunits, each of relative molecular mass (Mr)∼ 45,000 (refs 1–3). Recently, complementary DNA clones encoding these sub-units have been isolated and characterized along with that of a third subunit of unknown function, termed γ (refs 4–9). These studies revealed a primary structure for each subunit that was clearly similar to that of immunoglobulin and indicated a somatic rearrangement of corresponding genes that are also immunoglobulin-like. Recently, the analysis of the sequence organization of the T-cell receptor β-chain10–16 and T-cell-specific γ-chain gene families17 has been reported. We now present an initial characterization of the murine T-cell receptor α-chain gene family, and conclude that although it is clearly related to the gene families encoding immunoglobulins18, T-cell receptor β-chains10–16 and also T-cell γ-chains17, it shows unique characteristics. There is only a single constant (C) region gene segment, which is an exceptionally large distance (∼20–40 kilobases (kb) in the cases studied here) from joining (J) gene segments. In addition, the J cluster and the variable (V) segment number seem to be very large. Finally, in the case studied here, a complete α-chain gene shows no somatic mutation and can be assembled directly from Vα, Jα and Cα segments without inclusion of diversity (Dα) segments. More... »

PAGES

828-832

References to SciGraph publications

  • 1983-04. Somatic generation of antibody diversity in NATURE
  • 1984-12. Primary structure of human T-cell receptor α-chain in NATURE
  • 1980-08. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes in NATURE
  • 1984-09. The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor in NATURE
  • 1984-08. Localization of a T-cell receptor diversity-region element in NATURE
  • 1984-12. Complexity of human T-cell antigen receptor β-chain constant- and variable-region genes in NATURE
  • 1984-03. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains in NATURE
  • 1984-08. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes in NATURE
  • 1981-04. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes in NATURE
  • 1985-08. Genomic organization of the genes encoding mouse T-cell receptor α-chain in NATURE
  • 1985-08. Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor α-chain in NATURE
  • 1984-11. A third type of murine T-cell receptor gene in NATURE
  • 1981-04. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes in NATURE
  • 1979-07. Sequences at the somatic recombination sites of immunoglobulin light-chain genes in NATURE
  • 1979-02. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments in NATURE
  • 1984-11. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes in NATURE
  • 1984-03. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins in NATURE
  • 1984-05. Somatic recombination in a murine T-cell receptor gene in NATURE
  • 1984-06. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/316828a0

    DOI

    http://dx.doi.org/10.1038/316828a0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2993907


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    40 schema:description T lymphocytes recognize cell-bound antigens in the molecular context of the self major histocompatibility complex (MHC) gene products through the surface T-cell receptor(s). The minimal component of the T-cell receptor is a heterodimer composed of α and β subunits, each of relative molecular mass (Mr)∼ 45,000 (refs 1–3). Recently, complementary DNA clones encoding these sub-units have been isolated and characterized along with that of a third subunit of unknown function, termed γ (refs 4–9). These studies revealed a primary structure for each subunit that was clearly similar to that of immunoglobulin and indicated a somatic rearrangement of corresponding genes that are also immunoglobulin-like. Recently, the analysis of the sequence organization of the T-cell receptor β-chain10–16 and T-cell-specific γ-chain gene families17 has been reported. We now present an initial characterization of the murine T-cell receptor α-chain gene family, and conclude that although it is clearly related to the gene families encoding immunoglobulins18, T-cell receptor β-chains10–16 and also T-cell γ-chains17, it shows unique characteristics. There is only a single constant (C) region gene segment, which is an exceptionally large distance (∼20–40 kilobases (kb) in the cases studied here) from joining (J) gene segments. In addition, the J cluster and the variable (V) segment number seem to be very large. Finally, in the case studied here, a complete α-chain gene shows no somatic mutation and can be assembled directly from Vα, Jα and Cα segments without inclusion of diversity (Dα) segments.
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