Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-08-01

AUTHORS

E. Nisbet-Brown, R. K. Cheung, J. W. W. Lee, E. W. Gelfand

ABSTRACT

Calcium has been implicated as an intracellular messenger in the cellular response to various external stimuli. Exposure of lymphocytes to various mitogens and lectins results in rapid transmembrane calcium fluxes1–3 and increased cytoplasmic calcium concentrations ([Ca2+]i)4–7. It is not clear, however, whether the mechanisms by which these non-physiological stimuli activate cells are related to those involved in antigen-specific activation. We have now used antigen-specific T-cell clones8,9 to study changes in [Ca2+]i associated with specific activation and show here that these cells respond specifically in the presence of antigen and antigen-presenting cells (APC) with increased [Ca2+]i and that this increased [Ca2+]i shows the same genetic restrictions as are seen in the proliferation assay8,10,11. The kinetics of the [Ca2+]i response to antigen indicate that antigen undergoes a time-dependent processing step as a prerequisite for recognition by T cells, as has been shown for T-cell proliferative responses12–4, but that the [Ca2+]i response to processed antigen is extremely rapid. The close correlation between changes in [Ca2+]i and cell activation resulting in proliferation suggests that Ca2+ may act as an intracellular messenger in antigen-specific responses. More... »

PAGES

545-547

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/316545a0

DOI

http://dx.doi.org/10.1038/316545a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002094114

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3875796


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198 schema:name Division of Immunology/Rheumatology, Research Institute, Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Canada
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