Three types of neuronal calcium channel with different calcium agonist sensitivity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-08

AUTHORS

Martha C. Nowycky, Aaron P. Fox, Richard W. Tsien

ABSTRACT

How many types of calcium channels exist in neurones? This question is fundamental to understanding how calcium entry contributes to diverse neuronal functions such as transmitter release, neurite extension, spike initiation and rhythmic firing1–3. There is considerable evidence for the presence of more than one type of Ca conductance in neurones4–13 and other cells14–18. However, little is known about single-channel properties of diverse neuronal Ca channels, or their responsiveness to dihydropyridines, compounds widely used as labels in Ca channel purification19–21. Here we report evidence for the coexistence of three types of Ca channel in sensory neurones of the chick dorsal root ganglion. In addition to a large conductance channel that contributes long-lasting current at strong depolarizations (L), and a relatively tiny conductance that underlies a transient current activated at weak depolarizations (T), we find a third type of unitary activity (N) that is neither T nor L. N-type Ca channels require strongly negative potentials for complete removal of inactivation (unlike L) and strong depolarizations for activation (unlike T). The dihydropyridine Ca agonist Bay K 8644 strongly increases the opening probability of L-, but not T- or N-type channels. More... »

PAGES

440-443

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/316440a0

DOI

http://dx.doi.org/10.1038/316440a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017821234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2410796


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