1985-07-18
AUTHORSDayton T. Reardan, Claude F. Meares, David A. Goodwin, Maureen McTigue, Gary S. David, Mary R. Stone, Julia P. Leung, Richard M. Bartholomew, James M. Frincke
ABSTRACTBecause monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease1–3. Attachment of metal ions to antibodies by means of bifunctional chelating agents can add the diverse nuclear, physical and chemical properties of the metallic elements to these specific binding proteins (ref. 4 and refs therein). With the ultimate aim of engineering probe-binding properties into the antibodies themselves, we have now prepared monoclonal antibodies against the EDTA chelate of indium. These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude. These antibodies also introduce a new degree of control over the biological distributions of chelated radionuclides, markedly altering their uptake in tumours and normal organs. More... »
PAGES265-268
http://scigraph.springernature.com/pub.10.1038/316265a0
DOIhttp://dx.doi.org/10.1038/316265a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1029926210
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/3927170
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0302",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Inorganic Chemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibody Affinity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibody Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cations",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Edetic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Haptens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Indium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Structure-Activity Relationship",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Chemistry Department, University of California, 95616, Davis, California, USA",
"id": "http://www.grid.ac/institutes/grid.27860.3b",
"name": [
"Chemistry Department, University of California, 95616, Davis, California, USA"
],
"type": "Organization"
},
"familyName": "Reardan",
"givenName": "Dayton T.",
"id": "sg:person.0674667211.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674667211.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chemistry Department, University of California, 95616, Davis, California, USA",
"id": "http://www.grid.ac/institutes/grid.27860.3b",
"name": [
"Chemistry Department, University of California, 95616, Davis, California, USA"
],
"type": "Organization"
},
"familyName": "Meares",
"givenName": "Claude F.",
"id": "sg:person.01271112747.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271112747.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Veterans Administration Medical Center, 94304, Palo Alto, California, USA",
"id": "http://www.grid.ac/institutes/grid.280747.e",
"name": [
"Department of Radiology, Stanford University School of Medicine, 94305, Stanford, California, USA",
"Veterans Administration Medical Center, 94304, Palo Alto, California, USA"
],
"type": "Organization"
},
"familyName": "Goodwin",
"givenName": "David A.",
"id": "sg:person.01276675041.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276675041.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Veterans Administration Medical Center, 94304, Palo Alto, California, USA",
"id": "http://www.grid.ac/institutes/grid.280747.e",
"name": [
"Department of Radiology, Stanford University School of Medicine, 94305, Stanford, California, USA",
"Veterans Administration Medical Center, 94304, Palo Alto, California, USA"
],
"type": "Organization"
},
"familyName": "McTigue",
"givenName": "Maureen",
"id": "sg:person.01001514613.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001514613.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA",
"id": "http://www.grid.ac/institutes/grid.419947.6",
"name": [
"Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA"
],
"type": "Organization"
},
"familyName": "David",
"givenName": "Gary S.",
"id": "sg:person.015373114277.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015373114277.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA",
"id": "http://www.grid.ac/institutes/grid.419947.6",
"name": [
"Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA"
],
"type": "Organization"
},
"familyName": "Stone",
"givenName": "Mary R.",
"id": "sg:person.01034643243.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034643243.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA",
"id": "http://www.grid.ac/institutes/grid.419947.6",
"name": [
"Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA"
],
"type": "Organization"
},
"familyName": "Leung",
"givenName": "Julia P.",
"id": "sg:person.01102756443.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102756443.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA",
"id": "http://www.grid.ac/institutes/grid.419947.6",
"name": [
"Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA"
],
"type": "Organization"
},
"familyName": "Bartholomew",
"givenName": "Richard M.",
"id": "sg:person.01067577007.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067577007.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA",
"id": "http://www.grid.ac/institutes/grid.419947.6",
"name": [
"Hybritech, Inc., 11085 Torreyana Road, 92121, San Diego, California, USA"
],
"type": "Organization"
},
"familyName": "Frincke",
"givenName": "James M.",
"id": "sg:person.01337154710.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337154710.31"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/301258a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042241919",
"https://doi.org/10.1038/301258a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/256495a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001387921",
"https://doi.org/10.1038/256495a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4615-6761-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028667349",
"https://doi.org/10.1007/978-1-4615-6761-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/227680a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010419937",
"https://doi.org/10.1038/227680a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1985-07-18",
"datePublishedReg": "1985-07-18",
"description": "Because monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease1\u20133. Attachment of metal ions to antibodies by means of bifunctional chelating agents can add the diverse nuclear, physical and chemical properties of the metallic elements to these specific binding proteins (ref. 4 and refs therein). With the ultimate aim of engineering probe-binding properties into the antibodies themselves, we have now prepared monoclonal antibodies against the EDTA chelate of indium. These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude. These antibodies also introduce a new degree of control over the biological distributions of chelated radionuclides, markedly altering their uptake in tumours and normal organs.",
"genre": "article",
"id": "sg:pub.10.1038/316265a0",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2466051",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2634149",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2466657",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6025",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "316"
}
],
"keywords": [
"bifunctional chelating agent",
"metal chelates",
"metal ions",
"chelating agent",
"chemical properties",
"carriers of radionuclides",
"chelates",
"indium chelates",
"EDTA chelates",
"metallic elements",
"remarkable preference",
"orders of magnitude",
"biological distribution",
"properties",
"ions",
"molecules",
"atoms",
"metals",
"scandium",
"constants",
"gallium",
"radionuclides",
"indium",
"specific binding protein",
"carriers",
"attachment",
"agents",
"drugs",
"uptake",
"promise",
"binding protein",
"normal organs",
"protein",
"means",
"group",
"magnitude",
"order",
"degree",
"ultimate aim",
"distribution",
"monoclonal antibodies",
"use",
"elements",
"vivo",
"specific groups",
"new degree",
"antibodies",
"treatment",
"preferences",
"control",
"aim",
"antigen",
"tumor antigens",
"organs",
"tumors",
"diagnosis"
],
"name": "Antibodies against metal chelates",
"pagination": "265-268",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1029926210"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/316265a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"3927170"
]
}
],
"sameAs": [
"https://doi.org/10.1038/316265a0",
"https://app.dimensions.ai/details/publication/pub.1029926210"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:50",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_191.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/316265a0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/316265a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/316265a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/316265a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/316265a0'
This table displays all metadata directly associated to this object as RDF triples.
234 TRIPLES
21 PREDICATES
93 URIs
81 LITERALS
15 BLANK NODES