Antibodies against metal chelates View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-07-18

AUTHORS

Dayton T. Reardan, Claude F. Meares, David A. Goodwin, Maureen McTigue, Gary S. David, Mary R. Stone, Julia P. Leung, Richard M. Bartholomew, James M. Frincke

ABSTRACT

Because monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease1–3. Attachment of metal ions to antibodies by means of bifunctional chelating agents can add the diverse nuclear, physical and chemical properties of the metallic elements to these specific binding proteins (ref. 4 and refs therein). With the ultimate aim of engineering probe-binding properties into the antibodies themselves, we have now prepared monoclonal antibodies against the EDTA chelate of indium. These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude. These antibodies also introduce a new degree of control over the biological distributions of chelated radionuclides, markedly altering their uptake in tumours and normal organs. More... »

PAGES

265-268

Journal

TITLE

Nature

ISSUE

6025

VOLUME

316

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/316265a0

    DOI

    http://dx.doi.org/10.1038/316265a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029926210

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3927170


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