Individual-specific ‘fingerprints’ of human DNA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1985-07

AUTHORS

A. J. Jeffreys, V. Wilson, S. L. Thein

ABSTRACT

Simple tandem-repetitive regions of DNA (or ‘minisatellites’) which are dispersed in the human genome frequently show substantial length polymorphism arising from unequal exchanges which alter the number of short tandem repeats in a minisatellite1–4. We have shown previously that the repeat elements in a subset of human minisatellites share a common 10–15-base-pair (bp) ‘core’ sequence which might act as a recombination signal in the generation of these hypervariable regions5. A hybridization probe consisting of the core repeated in tandem can detect many highly polymorphic minisatellites simultaneously to provide a set of genetic markers of general use in human linkage analysis5. We now show that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing. More... »

PAGES

76-79

Journal

TITLE

Nature

ISSUE

6023

VOLUME

316

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/316076a0

    DOI

    http://dx.doi.org/10.1038/316076a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023556220

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2989708


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