Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-06

AUTHORS

Carl J. March, Bruce Mosley, Alf Larsen, Douglas Pat Cerretti, Gary Braedt, Virginia Price, Steven Gillis, Christopher S. Henney, Shirley R. Kronheim, Kenneth Grabstein, Paul J. Conlon, Thomas P. Hopp, David Cosman

ABSTRACT

Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity. More... »

PAGES

641-647

Journal

TITLE

Nature

ISSUE

6021

VOLUME

315

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/315641a0

    DOI

    http://dx.doi.org/10.1038/315641a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030171424

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2989698


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