Ontology type: schema:ScholarlyArticle Open Access: True
1985-02
AUTHORSA. Ullrich, J. R. Bell, E. Y. Chen, R. Herrera, L. M. Petruzzelli, T. J. Dull, A. Gray, L. Coussens, Y.-C. Liao, M. Tsubokawa, A. Mason, P. H. Seeburg, C. Grunfeld, O. M. Rosen, J. Ramachandran
ABSTRACTWe have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products. More... »
PAGES756-761
http://scigraph.springernature.com/pub.10.1038/313756a0
DOIhttp://dx.doi.org/10.1038/313756a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038715683
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/2983222
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Base Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Weight",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oncogenes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Conformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein-Tyrosine Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor, Epidermal Growth Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor, Insulin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Cell Surface",
"type": "DefinedTerm"
}
],
"author": [
{
"familyName": "Ullrich",
"givenName": "A.",
"id": "sg:person.01100307217.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100307217.91"
],
"type": "Person"
},
{
"familyName": "Bell",
"givenName": "J. R.",
"id": "sg:person.01142731207.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142731207.22"
],
"type": "Person"
},
{
"familyName": "Chen",
"givenName": "E. Y.",
"id": "sg:person.01041667325.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041667325.60"
],
"type": "Person"
},
{
"familyName": "Herrera",
"givenName": "R.",
"id": "sg:person.01323666331.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323666331.00"
],
"type": "Person"
},
{
"familyName": "Petruzzelli",
"givenName": "L. M.",
"id": "sg:person.01172357655.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172357655.00"
],
"type": "Person"
},
{
"familyName": "Dull",
"givenName": "T. J.",
"id": "sg:person.0637674375.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637674375.06"
],
"type": "Person"
},
{
"familyName": "Gray",
"givenName": "A.",
"id": "sg:person.0706007575.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706007575.00"
],
"type": "Person"
},
{
"familyName": "Coussens",
"givenName": "L.",
"id": "sg:person.01321341526.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321341526.55"
],
"type": "Person"
},
{
"familyName": "Liao",
"givenName": "Y.-C.",
"id": "sg:person.0630720657.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630720657.86"
],
"type": "Person"
},
{
"familyName": "Tsubokawa",
"givenName": "M.",
"id": "sg:person.01176212205.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176212205.49"
],
"type": "Person"
},
{
"familyName": "Mason",
"givenName": "A.",
"id": "sg:person.010213055312.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010213055312.90"
],
"type": "Person"
},
{
"familyName": "Seeburg",
"givenName": "P. H.",
"id": "sg:person.0765412570.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765412570.02"
],
"type": "Person"
},
{
"familyName": "Grunfeld",
"givenName": "C.",
"id": "sg:person.01121532077.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121532077.23"
],
"type": "Person"
},
{
"familyName": "Rosen",
"givenName": "O. M.",
"id": "sg:person.01022677103.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022677103.06"
],
"type": "Person"
},
{
"familyName": "Ramachandran",
"givenName": "J.",
"id": "sg:person.01326733504.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326733504.35"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1073/pnas.80.4.945",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000450941"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-2836(82)90515-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001452096"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/308037a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002290736",
"https://doi.org/10.1038/308037a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(84)90188-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002502298"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.79.22.6792",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009296945"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/309418a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009921132",
"https://doi.org/10.1038/309418a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0076-6879(83)91019-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009943699"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-2836(82)90069-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013548921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0968-0004(79)90201-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017155402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0968-0004(79)90201-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017155402"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/311631a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017410006",
"https://doi.org/10.1038/311631a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/11.8.2325",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019523674"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-291x(80)90360-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024850090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/9.10.2313",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024893843"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.74.12.5463",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025360556"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/311483a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030899800",
"https://doi.org/10.1038/311483a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.81.11.3327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031096534"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/311414a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031972428",
"https://doi.org/10.1038/311414a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/9.20.5233",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032915644"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-2836(75)80083-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033296365"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.77.12.7137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034674309"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.80.8.2137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036462887"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.80.1.133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038419166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-291x(82)80082-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039077047"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/303722a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039472144",
"https://doi.org/10.1038/303722a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0304-419x(84)90016-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040323826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0304-419x(84)90016-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040323826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/9.2.309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040425653"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.bi.46.070177.002043",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041459643"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/8.10.2331",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041490991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(80)90346-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041644727"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-5793(82)80094-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042567166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.pa.23.040183.002333",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045457025"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.77.3.1496",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048643003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.81.1.85",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049036655"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.76.10.4918",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049729665"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/311626a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049929455",
"https://doi.org/10.1038/311626a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/307521a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052686262",
"https://doi.org/10.1038/307521a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi00273a001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055168117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi00640a033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055183690"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.6849137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062641026"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.7031900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062643310"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo-104-5-1383",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064254221"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080256133",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080786552",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081606032",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1984.tb01812.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1081634005"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081646839",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081658633",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081678740",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081686323",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081687610",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081705228",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081711115",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081727660",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081942276",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082098306",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082105644",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082249837",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082660402",
"type": "CreativeWork"
}
],
"datePublished": "1985-02",
"datePublishedReg": "1985-02-01",
"description": "We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.",
"genre": "research_article",
"id": "sg:pub.10.1038/313756a0",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2466028",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2462040",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "6005",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "313"
}
],
"name": "Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes",
"pagination": "756-761",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b86cc54f0756faa3eb0811a9c4100ddcff36e8213210f38c29857bb727da70da"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"2983222"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/313756a0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1038715683"
]
}
],
"sameAs": [
"https://doi.org/10.1038/313756a0",
"https://app.dimensions.ai/details/publication/pub.1038715683"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:34",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000425.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/313756a0"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/313756a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/313756a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/313756a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/313756a0'
This table displays all metadata directly associated to this object as RDF triples.
379 TRIPLES
21 PREDICATES
102 URIs
36 LITERALS
24 BLANK NODES