Cloning and sequence analysis of a cDNA for rat transforming growth factor-α View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-02

AUTHORS

David C. Lee, Timothy M. Rose, Nancy R. Webb, George J. Todaro

ABSTRACT

Transforming growth factors (TGFs) are mitogenic polypeptides produced most conspicuously by transformed cells and conferring on normal cells several phenotypic alterations associated with transformation. TGFs comprise two distinct sets of molecules: TGF-alpha s are structurally similar to epidermal growth factor (EGF), binding to and inducing the tyrosine phosphorylation of the EGF receptor in a manner indistinguishable from that of EGF. In addition, the 50-amino acid rat TGF-alpha has 33 and 44% homologies with mouse and human EGFs, respectively, and shares with EGFs a conserved pattern of three disulphide bridges. Thus, it has been proposed that TGF-alpha s belong to a family of EGF-like polypeptides. TGF-beta s, on the other hand, display no measurable binding to EGF receptors, but potentiate the growth-stimulating activities of TGF-alpha. Here we report the isolation of a complementary DNA clone encoding rat TGF-alpha. This cDNA hybridizes to a 4.5-kilobase (kb) messenger RNA that is 30 times larger than necessary to code for a 50-amino acid polypeptide and is present not only in retrovirus-transformed rat cells but also at lower levels in normal rat tissues. The nucleotide sequence of the cDNA predicts that TGF-alpha is synthesized as a larger product and that the larger form may exist as a transmembrane protein. However, unlike many polypeptide hormones (including EGF), cleavage of the 50-amino acid TGF-alpha from the larger form does not occur at paired basic residues, but rather between alanine and valine residues, suggesting the role of a novel protease. More... »

PAGES

489

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/313489a0

DOI

http://dx.doi.org/10.1038/313489a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025119684

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3855503


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Recombinant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Lee", 
        "givenName": "David C.", 
        "id": "sg:person.01145003363.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145003363.79"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Rose", 
        "givenName": "Timothy M.", 
        "id": "sg:person.01311050601.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311050601.57"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Webb", 
        "givenName": "Nancy R.", 
        "id": "sg:person.0656665153.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656665153.55"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Todaro", 
        "givenName": "George J.", 
        "id": "sg:person.063643664.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063643664.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/313491a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004613802", 
          "https://doi.org/10.1038/313491a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj0780156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010753128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj0780156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010753128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.2.2.161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011955110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/257325a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022992282", 
          "https://doi.org/10.1038/257325a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(70)19051-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027995274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.50.070181.001533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032351522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(75)80083-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033296365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(83)90307-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034383059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/303722a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039472144", 
          "https://doi.org/10.1038/303722a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90550-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041222541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/11.6.1645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050781413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.75.8.4001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051169626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(80)65060-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052666855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.80.15.4684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053722724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00591a005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055181913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00709a025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055186060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6320373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062636753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6602382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080492322", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081663666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082082565", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1985-02", 
    "datePublishedReg": "1985-02-01", 
    "description": "Transforming growth factors (TGFs) are mitogenic polypeptides produced most conspicuously by transformed cells and conferring on normal cells several phenotypic alterations associated with transformation. TGFs comprise two distinct sets of molecules: TGF-alpha s are structurally similar to epidermal growth factor (EGF), binding to and inducing the tyrosine phosphorylation of the EGF receptor in a manner indistinguishable from that of EGF. In addition, the 50-amino acid rat TGF-alpha has 33 and 44% homologies with mouse and human EGFs, respectively, and shares with EGFs a conserved pattern of three disulphide bridges. Thus, it has been proposed that TGF-alpha s belong to a family of EGF-like polypeptides. TGF-beta s, on the other hand, display no measurable binding to EGF receptors, but potentiate the growth-stimulating activities of TGF-alpha. Here we report the isolation of a complementary DNA clone encoding rat TGF-alpha. This cDNA hybridizes to a 4.5-kilobase (kb) messenger RNA that is 30 times larger than necessary to code for a 50-amino acid polypeptide and is present not only in retrovirus-transformed rat cells but also at lower levels in normal rat tissues. The nucleotide sequence of the cDNA predicts that TGF-alpha is synthesized as a larger product and that the larger form may exist as a transmembrane protein. However, unlike many polypeptide hormones (including EGF), cleavage of the 50-amino acid TGF-alpha from the larger form does not occur at paired basic residues, but rather between alanine and valine residues, suggesting the role of a novel protease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/313489a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6002", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "313"
      }
    ], 
    "name": "Cloning and sequence analysis of a cDNA for rat transforming growth factor-\u03b1", 
    "pagination": "489", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "77abb00d72fc9a7ff987d52d46eba2bf19450b1ebe78f158c864dead87c588e8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3855503"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/313489a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025119684"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/313489a0", 
      "https://app.dimensions.ai/details/publication/pub.1025119684"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/313489a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/313489a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/313489a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/313489a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/313489a0'


 

This table displays all metadata directly associated to this object as RDF triples.

202 TRIPLES      21 PREDICATES      64 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/313489a0 schema:about N34663f902f44462dad4053b54d841475
2 N3f41632327e042c9aaa05d5b9c2d6150
3 N57837f491b0c41f48d42f7cea4d23999
4 N5e8b61b4a90e4a31a00d7ff4c033acb7
5 N78f14ab6d2ac497e953153ede0d91f8b
6 N7a4ab27b91f942e5b7dc1a163c5b9b78
7 N8640b44563d14fd6b47a6acc5c652e90
8 N95b49264e4644714b6afcb2765b4493a
9 Nc70ec45954124df69dca66f6cb7cb64a
10 Ncbe0c1e7e73c4d7d9fbb6ef367166719
11 Nd4fe60bbc68446acba5eddb3e9a257ad
12 Ndab32f248edd45b291493d60dfc589cf
13 Ne90993d0967744a78f5339de4ca69f89
14 Nef8ea976137f451aa69893b0840d68c8
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N7b08f54ac7c4497f8180ec56f6c61dfc
18 schema:citation sg:pub.10.1038/257325a0
19 sg:pub.10.1038/303722a0
20 sg:pub.10.1038/313491a0
21 https://app.dimensions.ai/details/publication/pub.1080492322
22 https://app.dimensions.ai/details/publication/pub.1081663666
23 https://app.dimensions.ai/details/publication/pub.1082082565
24 https://doi.org/10.1016/0042-6822(83)90307-0
25 https://doi.org/10.1016/0076-6879(70)19051-3
26 https://doi.org/10.1016/0092-8674(84)90550-6
27 https://doi.org/10.1016/s0022-2836(75)80083-0
28 https://doi.org/10.1016/s0076-6879(80)65060-5
29 https://doi.org/10.1021/bi00591a005
30 https://doi.org/10.1021/bi00709a025
31 https://doi.org/10.1042/bj0780156
32 https://doi.org/10.1073/pnas.75.8.4001
33 https://doi.org/10.1073/pnas.80.15.4684
34 https://doi.org/10.1093/nar/11.6.1645
35 https://doi.org/10.1126/science.6320373
36 https://doi.org/10.1126/science.6602382
37 https://doi.org/10.1128/mcb.2.2.161
38 https://doi.org/10.1146/annurev.bi.50.070181.001533
39 schema:datePublished 1985-02
40 schema:datePublishedReg 1985-02-01
41 schema:description Transforming growth factors (TGFs) are mitogenic polypeptides produced most conspicuously by transformed cells and conferring on normal cells several phenotypic alterations associated with transformation. TGFs comprise two distinct sets of molecules: TGF-alpha s are structurally similar to epidermal growth factor (EGF), binding to and inducing the tyrosine phosphorylation of the EGF receptor in a manner indistinguishable from that of EGF. In addition, the 50-amino acid rat TGF-alpha has 33 and 44% homologies with mouse and human EGFs, respectively, and shares with EGFs a conserved pattern of three disulphide bridges. Thus, it has been proposed that TGF-alpha s belong to a family of EGF-like polypeptides. TGF-beta s, on the other hand, display no measurable binding to EGF receptors, but potentiate the growth-stimulating activities of TGF-alpha. Here we report the isolation of a complementary DNA clone encoding rat TGF-alpha. This cDNA hybridizes to a 4.5-kilobase (kb) messenger RNA that is 30 times larger than necessary to code for a 50-amino acid polypeptide and is present not only in retrovirus-transformed rat cells but also at lower levels in normal rat tissues. The nucleotide sequence of the cDNA predicts that TGF-alpha is synthesized as a larger product and that the larger form may exist as a transmembrane protein. However, unlike many polypeptide hormones (including EGF), cleavage of the 50-amino acid TGF-alpha from the larger form does not occur at paired basic residues, but rather between alanine and valine residues, suggesting the role of a novel protease.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N471a42f01ae64aebaacff5080c5b1cdf
46 Nb33650fd4aa14346b16e2d2d2f697668
47 sg:journal.1018957
48 schema:name Cloning and sequence analysis of a cDNA for rat transforming growth factor-α
49 schema:pagination 489
50 schema:productId N01abbdd4c2a345dfb951ba7d15ace147
51 N559a4d89b15341cf9c5241bf8c9637d1
52 N8b544dfdde0344db9908de07d2b535b8
53 Nb00e34d61d7a471db796d3de04459a7d
54 Nb850ef2f2e6e4577949ffb665791a594
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025119684
56 https://doi.org/10.1038/313489a0
57 schema:sdDatePublished 2019-04-11T00:03
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N1043b883018c4890a694fa5b53296693
60 schema:url https://www.nature.com/articles/313489a0
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N01abbdd4c2a345dfb951ba7d15ace147 schema:name dimensions_id
65 schema:value pub.1025119684
66 rdf:type schema:PropertyValue
67 N1043b883018c4890a694fa5b53296693 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N34663f902f44462dad4053b54d841475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Plasmids
71 rdf:type schema:DefinedTerm
72 N38c1cdf0b11f4652a67b7bbe0d5110e8 rdf:first sg:person.01311050601.57
73 rdf:rest N710fdfbccbe14847a65d3f2c6c195843
74 N3f41632327e042c9aaa05d5b9c2d6150 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Nucleic Acid Hybridization
76 rdf:type schema:DefinedTerm
77 N471a42f01ae64aebaacff5080c5b1cdf schema:issueNumber 6002
78 rdf:type schema:PublicationIssue
79 N48283ec70a58451daf9bf79668bcbb71 rdf:first sg:person.063643664.94
80 rdf:rest rdf:nil
81 N559a4d89b15341cf9c5241bf8c9637d1 schema:name readcube_id
82 schema:value 77abb00d72fc9a7ff987d52d46eba2bf19450b1ebe78f158c864dead87c588e8
83 rdf:type schema:PropertyValue
84 N57837f491b0c41f48d42f7cea4d23999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Tissue Distribution
86 rdf:type schema:DefinedTerm
87 N5e8b61b4a90e4a31a00d7ff4c033acb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Cell Transformation, Neoplastic
89 rdf:type schema:DefinedTerm
90 N710fdfbccbe14847a65d3f2c6c195843 rdf:first sg:person.0656665153.55
91 rdf:rest N48283ec70a58451daf9bf79668bcbb71
92 N78f14ab6d2ac497e953153ede0d91f8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Base Sequence
94 rdf:type schema:DefinedTerm
95 N7a4ab27b91f942e5b7dc1a163c5b9b78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name RNA, Messenger
97 rdf:type schema:DefinedTerm
98 N7b08f54ac7c4497f8180ec56f6c61dfc rdf:first sg:person.01145003363.79
99 rdf:rest N38c1cdf0b11f4652a67b7bbe0d5110e8
100 N8640b44563d14fd6b47a6acc5c652e90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Animals
102 rdf:type schema:DefinedTerm
103 N8b544dfdde0344db9908de07d2b535b8 schema:name pubmed_id
104 schema:value 3855503
105 rdf:type schema:PropertyValue
106 N95b49264e4644714b6afcb2765b4493a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Rats
108 rdf:type schema:DefinedTerm
109 Nb00e34d61d7a471db796d3de04459a7d schema:name nlm_unique_id
110 schema:value 0410462
111 rdf:type schema:PropertyValue
112 Nb33650fd4aa14346b16e2d2d2f697668 schema:volumeNumber 313
113 rdf:type schema:PublicationVolume
114 Nb850ef2f2e6e4577949ffb665791a594 schema:name doi
115 schema:value 10.1038/313489a0
116 rdf:type schema:PropertyValue
117 Nc70ec45954124df69dca66f6cb7cb64a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cloning, Molecular
119 rdf:type schema:DefinedTerm
120 Ncbe0c1e7e73c4d7d9fbb6ef367166719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Membrane Proteins
122 rdf:type schema:DefinedTerm
123 Nd4fe60bbc68446acba5eddb3e9a257ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Peptides
125 rdf:type schema:DefinedTerm
126 Ndab32f248edd45b291493d60dfc589cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name DNA
128 rdf:type schema:DefinedTerm
129 Ne90993d0967744a78f5339de4ca69f89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name DNA, Recombinant
131 rdf:type schema:DefinedTerm
132 Nef8ea976137f451aa69893b0840d68c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Transforming Growth Factors
134 rdf:type schema:DefinedTerm
135 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
136 schema:name Biological Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
139 schema:name Biochemistry and Cell Biology
140 rdf:type schema:DefinedTerm
141 sg:journal.1018957 schema:issn 0090-0028
142 1476-4687
143 schema:name Nature
144 rdf:type schema:Periodical
145 sg:person.01145003363.79 schema:familyName Lee
146 schema:givenName David C.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145003363.79
148 rdf:type schema:Person
149 sg:person.01311050601.57 schema:familyName Rose
150 schema:givenName Timothy M.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311050601.57
152 rdf:type schema:Person
153 sg:person.063643664.94 schema:familyName Todaro
154 schema:givenName George J.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063643664.94
156 rdf:type schema:Person
157 sg:person.0656665153.55 schema:familyName Webb
158 schema:givenName Nancy R.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656665153.55
160 rdf:type schema:Person
161 sg:pub.10.1038/257325a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022992282
162 https://doi.org/10.1038/257325a0
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/303722a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039472144
165 https://doi.org/10.1038/303722a0
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/313491a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004613802
168 https://doi.org/10.1038/313491a0
169 rdf:type schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1080492322 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1081663666 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1082082565 schema:CreativeWork
173 https://doi.org/10.1016/0042-6822(83)90307-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034383059
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/0076-6879(70)19051-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027995274
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0092-8674(84)90550-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041222541
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/s0022-2836(75)80083-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033296365
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/s0076-6879(80)65060-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052666855
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1021/bi00591a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181913
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1021/bi00709a025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055186060
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1042/bj0780156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010753128
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1073/pnas.75.8.4001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051169626
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1073/pnas.80.15.4684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053722724
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1093/nar/11.6.1645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050781413
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1126/science.6320373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062636753
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1126/science.6602382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639150
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1128/mcb.2.2.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011955110
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1146/annurev.bi.50.070181.001533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032351522
202 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...