A point mutation in the Aγ-globin gene promoter in Greek hereditary persistence of fetal haemoglobin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-01

AUTHORS

Bernard G. Forget, Francis S. Collins, James E. Metherall, Julian Pan, Minoru Yamakawa, Sherman M. Weissman

ABSTRACT

Hereditary persistance of fetal haemoglobin (HPFH) is a benign condition characterized by the production in adulthood of more than 1% fetal haemoglobin (HbF, alpha 2 gamma 2) in the absence of erythropoietic stress. Several genetic types have been discerned based on the level of HbF produced, the relative contributions of the duplicated fetal (G gamma and A gamma) globin genes, and the presence or absence of deletions involving the beta and delta genes in cis to the mutation. Greek HPFH is a non-deletion variety in which heterozygotes produce 10-20% HbF, predominantly due to overproduction of the A gamma chain. We have cloned a 40-kilobase (kb) region of the beta-globin cluster from a Greek HPFH allele and report here that a point mutation (G----A) occurs 117 base pairs (bp) 5' to the cap site of the A gamma-globin gene, just upstream of the distal CCAAT sequence. The corresponding region of the G gamma-globin gene is normal. We discuss the implications of this finding for the developmental regulation of globin gene expression. More... »

PAGES

325

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/313325a0

DOI

http://dx.doi.org/10.1038/313325a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038846498

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2578620


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetal Hemoglobin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemoglobinopathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pedigree", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thalassemia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Forget", 
        "givenName": "Bernard G.", 
        "id": "sg:person.01061255657.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061255657.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Collins", 
        "givenName": "Francis S.", 
        "id": "sg:person.01041444737.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041444737.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Metherall", 
        "givenName": "James E.", 
        "id": "sg:person.01100261743.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100261743.48"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pan", 
        "givenName": "Julian", 
        "id": "sg:person.01214510343.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214510343.48"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yamakawa", 
        "givenName": "Minoru", 
        "id": "sg:person.01146375143.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146375143.62"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Weissman", 
        "givenName": "Sherman M.", 
        "id": "sg:person.01274452741.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274452741.92"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1979.tb03785.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001303435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1975.tb01807.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008516524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.77.3.1432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011223236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/296627a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011275466", 
          "https://doi.org/10.1038/296627a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1982.00361.x-i1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018931932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(83)90055-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023634452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.77.9.5201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024100683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(83)90217-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025100170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(80)90426-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026343971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.15.4894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029926017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.79.1.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032127041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(77)90272-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035888199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6603(08)60382-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038645287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/295120a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039538547", 
          "https://doi.org/10.1038/295120a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(82)90023-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046099222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1982.tb01934.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051697626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(81)90302-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052122925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6283634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062636034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076343776", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081611931", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1984.tb02187.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081620034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081670902", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081914744", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081928822", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1985-01", 
    "datePublishedReg": "1985-01-01", 
    "description": "Hereditary persistance of fetal haemoglobin (HPFH) is a benign condition characterized by the production in adulthood of more than 1% fetal haemoglobin (HbF, alpha 2 gamma 2) in the absence of erythropoietic stress. Several genetic types have been discerned based on the level of HbF produced, the relative contributions of the duplicated fetal (G gamma and A gamma) globin genes, and the presence or absence of deletions involving the beta and delta genes in cis to the mutation. Greek HPFH is a non-deletion variety in which heterozygotes produce 10-20% HbF, predominantly due to overproduction of the A gamma chain. We have cloned a 40-kilobase (kb) region of the beta-globin cluster from a Greek HPFH allele and report here that a point mutation (G----A) occurs 117 base pairs (bp) 5' to the cap site of the A gamma-globin gene, just upstream of the distal CCAAT sequence. The corresponding region of the G gamma-globin gene is normal. We discuss the implications of this finding for the developmental regulation of globin gene expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/313325a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435262", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440498", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6000", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "313"
      }
    ], 
    "name": "A point mutation in the A\u03b3-globin gene promoter in Greek hereditary persistence of fetal haemoglobin", 
    "pagination": "325", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b90c319be3134addc98fc01525ec6242b1f46a88d57bc2fe57c62affb4f9ba2e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2578620"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/313325a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038846498"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/313325a0", 
      "https://app.dimensions.ai/details/publication/pub.1038846498"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/313325a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/313325a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/313325a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/313325a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/313325a0'


 

This table displays all metadata directly associated to this object as RDF triples.

208 TRIPLES      21 PREDICATES      63 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/313325a0 schema:about N33bc387ab4054d798d6a16c9cca38580
2 N4cca1f80ca2a464caeee7b63fd286148
3 N54261fd001414683b17ed52191e9ee3d
4 N59394f334f684ee7927d323464195585
5 N61f023accb014730b6a0859f8eee315e
6 N9b9c3e74fa584450ba0d227dc2e63a6c
7 Naa4b90e42c0f4be29a7fb29108983990
8 Nbdd900a848184ea6b564c3b0373aaeaa
9 Nbf1ce7e59f7740fb9fb0fe8200d4c96d
10 Nefdfef69d7234374801dd1c5ad906faa
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author Nd3d3af1a6cdd4a2fb9f718f10d56fb4c
14 schema:citation sg:pub.10.1038/295120a0
15 sg:pub.10.1038/296627a0
16 https://app.dimensions.ai/details/publication/pub.1076343776
17 https://app.dimensions.ai/details/publication/pub.1081611931
18 https://app.dimensions.ai/details/publication/pub.1081670902
19 https://app.dimensions.ai/details/publication/pub.1081914744
20 https://app.dimensions.ai/details/publication/pub.1081928822
21 https://doi.org/10.1002/j.1460-2075.1984.tb02187.x
22 https://doi.org/10.1016/0092-8674(77)90272-0
23 https://doi.org/10.1016/0092-8674(80)90426-2
24 https://doi.org/10.1016/0092-8674(81)90302-0
25 https://doi.org/10.1016/0092-8674(82)90023-x
26 https://doi.org/10.1016/0092-8674(83)90055-7
27 https://doi.org/10.1016/0092-8674(83)90217-9
28 https://doi.org/10.1016/s0079-6603(08)60382-7
29 https://doi.org/10.1073/pnas.77.3.1432
30 https://doi.org/10.1073/pnas.77.9.5201
31 https://doi.org/10.1073/pnas.79.1.137
32 https://doi.org/10.1073/pnas.81.15.4894
33 https://doi.org/10.1111/j.1365-2141.1975.tb01807.x
34 https://doi.org/10.1111/j.1365-2141.1979.tb03785.x
35 https://doi.org/10.1111/j.1365-2141.1982.00361.x-i1
36 https://doi.org/10.1111/j.1365-2141.1982.tb01934.x
37 https://doi.org/10.1126/science.6283634
38 schema:datePublished 1985-01
39 schema:datePublishedReg 1985-01-01
40 schema:description Hereditary persistance of fetal haemoglobin (HPFH) is a benign condition characterized by the production in adulthood of more than 1% fetal haemoglobin (HbF, alpha 2 gamma 2) in the absence of erythropoietic stress. Several genetic types have been discerned based on the level of HbF produced, the relative contributions of the duplicated fetal (G gamma and A gamma) globin genes, and the presence or absence of deletions involving the beta and delta genes in cis to the mutation. Greek HPFH is a non-deletion variety in which heterozygotes produce 10-20% HbF, predominantly due to overproduction of the A gamma chain. We have cloned a 40-kilobase (kb) region of the beta-globin cluster from a Greek HPFH allele and report here that a point mutation (G----A) occurs 117 base pairs (bp) 5' to the cap site of the A gamma-globin gene, just upstream of the distal CCAAT sequence. The corresponding region of the G gamma-globin gene is normal. We discuss the implications of this finding for the developmental regulation of globin gene expression.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N1ffc530afc444512bccfabff7391d7b4
45 Nae609d94c58448e88fd32a9c27f4b8a2
46 sg:journal.1018957
47 schema:name A point mutation in the Aγ-globin gene promoter in Greek hereditary persistence of fetal haemoglobin
48 schema:pagination 325
49 schema:productId N76c26338d1524a97b32b0f68663b3e89
50 Na315244e33f64354a65553b4931fddc3
51 Naf46589787014f7791576a01153fba66
52 Nd2e37268f64d483a94af7ce8242a7b1b
53 Nea12bf971e0e4b9d8b1913453443c5cd
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038846498
55 https://doi.org/10.1038/313325a0
56 schema:sdDatePublished 2019-04-10T12:59
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N667bb4d57d4b4957aef36db6c20e3627
59 schema:url https://www.nature.com/articles/313325a0
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N1ffc530afc444512bccfabff7391d7b4 schema:volumeNumber 313
64 rdf:type schema:PublicationVolume
65 N33bc387ab4054d798d6a16c9cca38580 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Promoter Regions, Genetic
67 rdf:type schema:DefinedTerm
68 N4cca1f80ca2a464caeee7b63fd286148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Mutation
70 rdf:type schema:DefinedTerm
71 N54261fd001414683b17ed52191e9ee3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Fetal Hemoglobin
73 rdf:type schema:DefinedTerm
74 N54f59c38c8f94ca9b4bb564877a0b82e rdf:first sg:person.01100261743.48
75 rdf:rest N764a5e4de71541a2b4aae27af08a55ad
76 N59394f334f684ee7927d323464195585 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Globins
78 rdf:type schema:DefinedTerm
79 N61f023accb014730b6a0859f8eee315e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Hemoglobinopathies
81 rdf:type schema:DefinedTerm
82 N667bb4d57d4b4957aef36db6c20e3627 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N764a5e4de71541a2b4aae27af08a55ad rdf:first sg:person.01214510343.48
85 rdf:rest Nb1e99f500d4a46ce983de8e6bb4e0985
86 N76c26338d1524a97b32b0f68663b3e89 schema:name readcube_id
87 schema:value b90c319be3134addc98fc01525ec6242b1f46a88d57bc2fe57c62affb4f9ba2e
88 rdf:type schema:PropertyValue
89 N9b9c3e74fa584450ba0d227dc2e63a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Pedigree
91 rdf:type schema:DefinedTerm
92 Na315244e33f64354a65553b4931fddc3 schema:name dimensions_id
93 schema:value pub.1038846498
94 rdf:type schema:PropertyValue
95 Naa4b90e42c0f4be29a7fb29108983990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name DNA
97 rdf:type schema:DefinedTerm
98 Nae609d94c58448e88fd32a9c27f4b8a2 schema:issueNumber 6000
99 rdf:type schema:PublicationIssue
100 Naf46589787014f7791576a01153fba66 schema:name doi
101 schema:value 10.1038/313325a0
102 rdf:type schema:PropertyValue
103 Nb1e99f500d4a46ce983de8e6bb4e0985 rdf:first sg:person.01146375143.62
104 rdf:rest Ndc75775291914e65a772d337d7da860a
105 Nbdd900a848184ea6b564c3b0373aaeaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Thalassemia
107 rdf:type schema:DefinedTerm
108 Nbf1ce7e59f7740fb9fb0fe8200d4c96d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Humans
110 rdf:type schema:DefinedTerm
111 Nd2e37268f64d483a94af7ce8242a7b1b schema:name nlm_unique_id
112 schema:value 0410462
113 rdf:type schema:PropertyValue
114 Nd3d3af1a6cdd4a2fb9f718f10d56fb4c rdf:first sg:person.01061255657.32
115 rdf:rest Nd756177ceaa04ac3897a942d60f38385
116 Nd756177ceaa04ac3897a942d60f38385 rdf:first sg:person.01041444737.29
117 rdf:rest N54f59c38c8f94ca9b4bb564877a0b82e
118 Ndc75775291914e65a772d337d7da860a rdf:first sg:person.01274452741.92
119 rdf:rest rdf:nil
120 Nea12bf971e0e4b9d8b1913453443c5cd schema:name pubmed_id
121 schema:value 2578620
122 rdf:type schema:PropertyValue
123 Nefdfef69d7234374801dd1c5ad906faa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Base Sequence
125 rdf:type schema:DefinedTerm
126 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
127 schema:name Biological Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
130 schema:name Genetics
131 rdf:type schema:DefinedTerm
132 sg:grant.2435262 http://pending.schema.org/fundedItem sg:pub.10.1038/313325a0
133 rdf:type schema:MonetaryGrant
134 sg:grant.2440498 http://pending.schema.org/fundedItem sg:pub.10.1038/313325a0
135 rdf:type schema:MonetaryGrant
136 sg:journal.1018957 schema:issn 0090-0028
137 1476-4687
138 schema:name Nature
139 rdf:type schema:Periodical
140 sg:person.01041444737.29 schema:familyName Collins
141 schema:givenName Francis S.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041444737.29
143 rdf:type schema:Person
144 sg:person.01061255657.32 schema:familyName Forget
145 schema:givenName Bernard G.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061255657.32
147 rdf:type schema:Person
148 sg:person.01100261743.48 schema:familyName Metherall
149 schema:givenName James E.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100261743.48
151 rdf:type schema:Person
152 sg:person.01146375143.62 schema:familyName Yamakawa
153 schema:givenName Minoru
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146375143.62
155 rdf:type schema:Person
156 sg:person.01214510343.48 schema:familyName Pan
157 schema:givenName Julian
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214510343.48
159 rdf:type schema:Person
160 sg:person.01274452741.92 schema:familyName Weissman
161 schema:givenName Sherman M.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274452741.92
163 rdf:type schema:Person
164 sg:pub.10.1038/295120a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039538547
165 https://doi.org/10.1038/295120a0
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/296627a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011275466
168 https://doi.org/10.1038/296627a0
169 rdf:type schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1076343776 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1081611931 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1081670902 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1081914744 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1081928822 schema:CreativeWork
175 https://doi.org/10.1002/j.1460-2075.1984.tb02187.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081620034
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0092-8674(77)90272-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035888199
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0092-8674(80)90426-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026343971
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0092-8674(81)90302-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052122925
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0092-8674(82)90023-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046099222
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0092-8674(83)90055-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023634452
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0092-8674(83)90217-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025100170
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/s0079-6603(08)60382-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038645287
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1073/pnas.77.3.1432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011223236
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1073/pnas.77.9.5201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024100683
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1073/pnas.79.1.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032127041
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1073/pnas.81.15.4894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029926017
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1111/j.1365-2141.1975.tb01807.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008516524
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1111/j.1365-2141.1979.tb03785.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001303435
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1111/j.1365-2141.1982.00361.x-i1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018931932
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1111/j.1365-2141.1982.tb01934.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051697626
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1126/science.6283634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062636034
208 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...