Cloning, sequence and expression of human interleukin-2 receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-12

AUTHORS

David Cosman, Douglas Pat Cerretti, Alf Larsen, Linda Park, Carl March, Steven Dower, Steven Gillis, David Urdal

ABSTRACT

T lymphocytes, essential for the generation of a normal immune response, require the presence of the lymphokine interleukin-2 (IL-2) in order to proliferate1,2. Cells that respond to IL-2 possess a surface receptor glycoprotein specific for this lymphokine3,4. We have recently purified and chemically characterized the IL-2 receptor from both phytohaemagglutinin-activated human T cells and the human T-cell lymphoma HUT-102 (ref. 5). From the NH2-terminal protein sequence obtained in that study, we have now used synthetic oligonucleotides to probe a complementary DNA library, prepared from HUT-102 messenger RNA, for the presence of cDNA clones that might code for the IL-2 receptor. Two cDNA clones were isolated which had closely related DNA sequences. Interestingly, only one coded for an active receptor when transfected into COS-7 cells. This clone contained a 216-base pair (bp) insert that was not present in the other clone. The insert was flanked by an 8-bp direct repeat reminiscent of a transposable element, and appeared to code for a region of marked structural homology to the NH2-terminal region of the receptor molecule. More... »

PAGES

768-771

Journal

TITLE

Nature

ISSUE

5996

VOLUME

312

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/312768a0

    DOI

    http://dx.doi.org/10.1038/312768a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006513112

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6096720


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