Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-06

AUTHORS

Y R Zou, A H Kottmann, M Kuroda, I Taniuchi, D R Littman

ABSTRACT

Chemokines and their receptors are important in cell migration during inflammation, in the establishment of functional lymphoid microenvironments, and in organogenesis. The chemokine receptor CXCR4 is broadly expressed in cells of both the immune and the central nervous systems and can mediate migration of resting leukocytes and haematopoietic progenitors in response to its ligand, SDF-1. CXCR4 is also a major receptor for strains of human immunodeficiency virus-1 (HIV-1) that arise during progression to immunodeficiency and AIDS dementia. Here we show that mice lacking CXCR4 exhibit haematopoietic and cardiac defects identical to those of SDF-1-deficient mice, indicating that CXCR4 may be the only receptor for SDF-1. Furthermore, fetal cerebellar development in mutant animals is markedly different from that in wild-type animals, with many proliferating granule cells invading the cerebellar anlage. This is, to our knowledge, the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system. These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia. More... »

PAGES

595-599

Journal

TITLE

Nature

ISSUE

6685

VOLUME

393

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/31269

    DOI

    http://dx.doi.org/10.1038/31269

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048977106

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9634238


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