Multiple specific contacts between a mammalian transcription factor and its cognate promoters View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-11

AUTHORS

David Gidoni, William S. Dynan, Robert Tjian

ABSTRACT

The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of these sequences forming close contacts with Sp1. The clustered contacts fall on one strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters. More... »

PAGES

409-413

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/312409a0

DOI

http://dx.doi.org/10.1038/312409a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040175737

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6095100


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