Structure, expression and divergence of T-cell receptor β-chain variable regions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-11

AUTHORS

Phillip Patten, Takashi Yokota, Jonathan Rothbard, Yueh-hsiu Chien, Ken-ichi Arai, Mark M. Davis

ABSTRACT

Analysis of three new T-cell receptor β-chain variable regions together with those in the literature indicates that they have both remarkable similarities and differences with those of immunoglobulin. Less than 10 V regions appear to predominate in the thymus. Vβ sequences are much more heterogeneous at the amino acid level than are immunoglobulin V regions and they appear to diverge between species much more quickly, apparently the result of additional hypervariable regions. Three of these putative new hypervariable regions lie outside of the classical immunoglobulin binding site, an indication that important interactions may be occurring in these regions with polymorphic MHC determinants. More... »

PAGES

40-46

Journal

TITLE

Nature

ISSUE

5989

VOLUME

312

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/312040a0

DOI

http://dx.doi.org/10.1038/312040a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017809705

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6092964


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