A third type of murine T-cell receptor gene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-11

AUTHORS

Yueh-hsiu Chien, Daniel M. Becker, Tullia Lindsten, Maki Okamura, David I. Cohen, Mark M. Davis

ABSTRACT

By subtractive cDNA hybridizations, we have isolated a new species of T-cell receptor cDNA clone whose predicted amino acid sequence has homology to variable, constant, joining and diversity segments of immunoglobulins and T-cell receptors. The corresponding genomic sequence is also rearranged in several T-cell DNAs. The four potential N-linked glycosylation sites, frequency of expression and predicted molecular weight (27,800) of this molecule make it a likely candidate for the alpha-chain of the T-cell receptor. Expression data also indicate that this gene may be activated at a later stage of T-cell differentiation than the beta-chain. More... »

PAGES

31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/312031a0

DOI

http://dx.doi.org/10.1038/312031a0

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6548551


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