A novel transforming gene in a human malignant melanoma cell line View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-10

AUTHORS

R. A. Padua, N. Barrass, G. A. Currie

ABSTRACT

Cellular transforming genes can be detected in human tumours by DNA-mediated transfection into NIH 3T3 mouse fibroblasts1,2. The activated transforming genes have been, in most cases, members of the ras gene family, of which the most frequently found is the c-Ki-ras oncogene3–7 and least frequently the c-Ha-ras gene8–10. An increasing number of studies has identified the presence of activated N-ras (which has no known viral homologue) in human tumour cell lines11–18. Furthermore, other transforming genes, distinct from the ras gene family, have been reported in B-and T-cell lymphomas19,20. The activation of c-Ha-ras and N-ras has been described in some cell lines derived from cases of human malignant melanoma21. Here we describe the presence of transforming activity in the DNA from a human melanoma cell line which shows weak homology with members of the ras oncogene family. More... »

PAGES

671-673

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/311671a0

DOI

http://dx.doi.org/10.1038/311671a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003247298

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6090953


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