Abrogation of resistance to bone marrow transplantation by induction of specific tolerance in natural killer cells? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-10

AUTHORS

Martin Waterfall, Lee S. Rayfield, Leslie Brent

ABSTRACT

Hybrid resistance describes the capacity of first generation (F1) hybrids between certain mouse strains to inhibit the growth of tumour or haematopoietic cells of parental origin1,2. The cells that appear to mediate this phenomenon differ from classical T and B lymphocytes in several respects. For example, they are unusually radioresistant3, show no immunological memory4, are present in thymectomized5 or congenitally athymic6 mice, and are not functional until about 3 weeks after birth3,4. These characteristics suggest that the effectors are natural killer (NK) cells7. Although most of the evidence implicating NK cells in hybrid resistance is circumstantial, the experiments of Warner and Dennert8 are more direct in that they show that resistance can be restored to mice with a congenital or induced defect in NK activity by the infusion of cells belonging to an NK clone. Conversely, treatment of mice with an antibody to NK cells abrogated hybrid resistance to parental bone marrow grafts9. Both NK cells and the effectors of hybrid resistance are generally considered to be nonspecific. We have now investigated this assumption by attempting to prevent hybrid resistance by neonatal tolerance induction with parental strain antigens. Our data indicate that hybrid resistance can be abrogated by this means and that the tolerance is specific and transferable with Thy-1+ spleen cells. More... »

PAGES

663-665

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/311663a0

DOI

http://dx.doi.org/10.1038/311663a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008938628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6384795


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