A Ca-dependent Cl− conductance in cultured mouse spinal neurones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-10

AUTHORS

David G. Owen, Menahem Segal, Jeffery L. Barker

ABSTRACT

Long-lasting conductance changes triggered either by brief (millisecond) electrical stimuli and/or entry of calcium ions have been observed in a variety of excitable tissues. The electrical consequences of these events depend on the ion conductance affected and on the ion concentration gradient across the membrane, while the long-lasting nature of the change sustains the cell at either sub- or supra-threshold levels for activation of regenerative action potentials. We report here that many cultured mouse spinal neurones exhibit a voltage-activated chloride conductance that lasts for seconds and is dependent on extracellular calcium, [Ca2+]0. This conductance may repolarize and stabilize the cell at a level subthreshold for generating action potentials, thus complementing the functional roles of Ca-dependent K+ conductances. More... »

PAGES

567

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/311567a0

DOI

http://dx.doi.org/10.1038/311567a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031104853

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6482969


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