Comparative biochemical properties of normal and activated human ras p21 protein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-08

AUTHORS

John P. McGrath, Daniel J. Capon, David V. Goeddel, Arthur D. Levinson

ABSTRACT

Human Ha-ras1 cDNAs encoding normal and activated p21 polypeptides have been efficiently expressed in Escherichia coli and the biochemical activities associated with each polypeptide compared. In addition to the guanine nucleotide binding activity, normal p21 displays a GTPase activity which is selectively impaired by a mutation which activates its oncogenic potential More... »

PAGES

644-649

References to SciGraph publications

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  • 1982-04. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells in NATURE
  • 1983-01. Homology between human bladder carcinoma oncogene product and mitochondrial ATP-synthase in NATURE
  • 1981-08. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes in NATURE
  • 1983-04. Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant in NATURE
  • 1980-10. Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus in NATURE
  • 1980-04. Transforming activity of DNA of chemically transformed and normal cells in NATURE
  • 1983-03. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/310644a0

    DOI

    http://dx.doi.org/10.1038/310644a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022789864

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6147754


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