Comparative biochemical properties of normal and activated human ras p21 protein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-08

AUTHORS

John P. McGrath, Daniel J. Capon, David V. Goeddel, Arthur D. Levinson

ABSTRACT

Human Ha-ras1 cDNAs encoding normal and activated p21 polypeptides have been efficiently expressed in Escherichia coli and the biochemical activities associated with each polypeptide compared. In addition to the guanine nucleotide binding activity, normal p21 displays a GTPase activity which is selectively impaired by a mutation which activates its oncogenic potential. More... »

PAGES

644-649

References to SciGraph publications

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  • 1982-11. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene in NATURE
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  • 1979-10. Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone in NATURE
  • 1983-06. Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene in NATURE
  • 1982-02. Bacterial expression of an enzymatically active protein encoded by RSV src gene in NATURE
  • 1981-03. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts in NATURE
  • 1980-04. Transforming activity of DNA of chemically transformed and normal cells in NATURE
  • 1982-06. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus in NATURE
  • 1980-10. Human leukocyte interferon produced by E. coli is biologically active in NATURE
  • 1983-01. Homology between human bladder carcinoma oncogene product and mitochondrial ATP-synthase in NATURE
  • 1981-08. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes in NATURE
  • 1983-08. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene in NATURE
  • 1983-03. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue in NATURE
  • 1983-04. Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant in NATURE
  • 1982-04. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/310644a0

    DOI

    http://dx.doi.org/10.1038/310644a0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6147754


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