A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-08

AUTHORS

E Carbone, H D Lux

ABSTRACT

Calcium channels in excitable membranes are essential for many cellular functions. Recent analyses of the burst-firing mode of some vertebrate neurones suggest that changes in their functional state are controlled by a Ca conductance that is largely inactivated at resting membrane potentials (-50 to -60 mV), but becomes activated following a conditioning hyperpolarization of the cell membrane. Here, using chick and rat sensory neurones, we present evidence for a new type of Ca channel with time- and voltage-dependent properties which is probably responsible for the inactivation behaviour of the Ca conductance. At membrane potentials between -50 and +10 mV, openings of this channel last 3-6 ms and tend to occur in rapid succession. Inactivation of this channel is indicated by prolonged and eventually complete closures brought about by long-lasting depolarizing voltage steps. This channel coexists in isolated membrane patches with the more common Ca channel which is less sensitive to changes in holding potential and shows a considerably shorter average life time and smaller currents. More... »

PAGES

501-502

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/310501a0

DOI

http://dx.doi.org/10.1038/310501a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045389050

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6087159


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