Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-07

AUTHORS

John C. W. Shepherd, William McGinnis, Andrés E. Carrasco, Eddy M. De Robertis, Walter J. Gehring

ABSTRACT

Homoeotic genes in the bithorax and Antennapedia complexes of Drosophila melanogaster appear to specify the developmental fate of segments of the fly. Some of these genes (Ultrabithorax, Antennapedia and fushi tarazu) share homology due to their conservation of a ‘homoeo domain’1,2 consisting of 60 amino acids. Cross-hybridization and cloning experiments show that the homoeo domain is conserved in a frog (Xenopus laevis) gene expressed in early development3 and may also be present in earthworm, beetle, chicken, mouse and human genomes2. The extreme conservation found in the amino acid sequences between the Drosophila and Xenopus domains suggests that the domain has a vital function in the control of early development. Here we report the results of a search made in the Dayhoff sequence bank, which reveals a lesser but apparently significant homology between the homoeo domain and the amino acids coded from parts of the a1 and α2 mating type genes of the yeast Saccharomyces cerevisiae4,5. More... »

PAGES

70-71

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/310070a0

DOI

http://dx.doi.org/10.1038/310070a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036385923

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6429549


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