Cellular transformation by coordinated action of three peptide growth factors from human platelets View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-06

AUTHORS

Richard K. Assoian, Gary R. Grotendorst, Dorothea M. Miller, Michael B. Sporn

ABSTRACT

Platelet-derived growth factor (PDGF) is known to be involved in regulating the mitosis of connective tissue cells, and recent studies have also shown that it may function in mediating cellular transformation. The oncogene carried by simian sarcoma virus, sis, is homologous to one chain of PDGF, and treatment of non-neoplastic cells with this growth factor results in increased transcription of another oncogene, myc (ref. 9). PDGF also stimulates the synthesis of proteins that are characteristic of transformed cells. However, phenotypic transformation does not appear to result from the action of PDGF alone. For example, expression of myc does not transform cells in the absence of other oncogene expression. We have recently shown that platelets contain another peptide growth factor, transforming growth factor-beta (TGF-beta)12,13, in addition to PDGF. We report here that extracts of human platelets can induce anchorage-independent growth of nonneoplastic rat kidney (NRK) fibroblasts, but that purified PDGF alone does not elicit this effect. Rather, the transforming activity of the platelet extract is due to a concerted action of three distinct peptides: PDGF, TGF-ss and a newly identified analogue of epidermal growth factor (EGF). More... »

PAGES

804-806

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/309804a0

DOI

http://dx.doi.org/10.1038/309804a0

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6330562


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63 schema:description Platelet-derived growth factor (PDGF) is known to be involved in regulating the mitosis of connective tissue cells, and recent studies have also shown that it may function in mediating cellular transformation. The oncogene carried by simian sarcoma virus, sis, is homologous to one chain of PDGF, and treatment of non-neoplastic cells with this growth factor results in increased transcription of another oncogene, myc (ref. 9). PDGF also stimulates the synthesis of proteins that are characteristic of transformed cells. However, phenotypic transformation does not appear to result from the action of PDGF alone. For example, expression of myc does not transform cells in the absence of other oncogene expression. We have recently shown that platelets contain another peptide growth factor, transforming growth factor-beta (TGF-beta)12,13, in addition to PDGF. We report here that extracts of human platelets can induce anchorage-independent growth of nonneoplastic rat kidney (NRK) fibroblasts, but that purified PDGF alone does not elicit this effect. Rather, the transforming activity of the platelet extract is due to a concerted action of three distinct peptides: PDGF, TGF-ss and a newly identified analogue of epidermal growth factor (EGF).
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