Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic poly peptide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-06

AUTHORS

Shinzo Oikawa, Mayumi Imai, Atsuko Ueno, Shoji Tanaka, Teruhisa Noguchi, Hiroshi Nakazato, Kenki Kangawa, Ayako Fukuda, Hisayuki Matsuo

ABSTRACT

Recent identification of natriuretic–diuretic activity in peptides isolated from human1 and rat 2–5 atrial tissue implicates them in the control of extracellular fluid volume and electrolytic homeostasis. The presence of multiple forms of the peptides ranging from 3,000 to 13,000 molecular weight (MW) suggests they may all derive from the same precursor1–6. The established amino acid sequence of α-human atrial natriuretic poly peptide (α-hANP)1, a 28-residue peptide with potent natriuretic activity, provided the means to elucidate the structure of the precursor for α-hANP and the gene encoding it. Here we report the cloning and sequence analysis of the cDNA of human atrial mRNA encoding a precursor of α-hANP. The cDNA encodes γ-human atrial natriuretic polypeptide (γ-hANP) of 13,000 MW, whose C-terminal 28 amino acid residues may be processed as α-hANP. More... »

PAGES

724-726

Journal

TITLE

Nature

ISSUE

5970

VOLUME

309

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/309724a0

DOI

http://dx.doi.org/10.1038/309724a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019610738

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6203042


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