Evolution of phosphofructokinase—gene duplication and creation of new effector sites View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-05

AUTHORS

Roger A. Poorman, Anne Randolph, Robert G. Kemp, Robert L. Heinrikson

ABSTRACT

Phosphofructokinases (PFK; EC 2.7.1.11) are tetrameric enzymes that have a key role in the regulation of glycolysis; as such, they are subject to allosteric activation and inhibition by various metabolites. Eukaryotic PFKs are about twice the size of prokaryotic enzymes and are regulated by a wider repertoire of effectors: for example, the subunit molecular weights of rabbit muscle (RM) PFK and Bacillus stearothermophilus (Bs) PFK are 82,000 and 36,000, respectively. Both enzymes are activated by ADP (or AMP), but RM-PFK is also activated by fructose bisphosphates (FBP) and inhibited by ATP and citrate. This, together with other evidence, has led to speculation that mammalian PFKs have evolved by duplication of a prokaryotic gene, although previous peptide analysis failed to reveal internal homology in RM-PFK. Here we demonstrate clear homology among the N- and C-halves of RM-PFK and Bs-PFK, thus establishing an evolutionary relationship by series gene duplication and divergence. Furthermore, detailed knowledge of the Bs-PFK structure provides the basis for inferences concerning the structural organization of RM-PFK and the evolution of new effector sites in the enzyme tetramer. More... »

PAGES

467-469

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/309467a0

DOI

http://dx.doi.org/10.1038/309467a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002565920

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6233492


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Evolution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Geobacillus stearothermophilus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphofructokinase-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Poorman", 
        "givenName": "Roger A.", 
        "id": "sg:person.0752620410.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752620410.41"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Randolph", 
        "givenName": "Anne", 
        "id": "sg:person.01333234315.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333234315.23"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kemp", 
        "givenName": "Robert G.", 
        "id": "sg:person.01173533437.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173533437.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Heinrikson", 
        "givenName": "Robert L.", 
        "id": "sg:person.073472130.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073472130.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0022-2836(68)90316-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010887142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1976.tb10785.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012231114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00849191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013139564", 
          "https://doi.org/10.1007/bf00849191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00849191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013139564", 
          "https://doi.org/10.1007/bf00849191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(74)90027-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032674261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(70)90372-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033069770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(81)90227-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034294391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470122938.ch4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037133383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/279500a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051644922", 
          "https://doi.org/10.1038/279500a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/279500a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051644922", 
          "https://doi.org/10.1038/279500a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1980.tb04754.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053213746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00274a014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055168183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00288a039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055168802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00673a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055184819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00746a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055187214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00854a009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055191144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080203838", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080236926", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081651972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081748086", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081750828", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1984-05", 
    "datePublishedReg": "1984-05-01", 
    "description": "Phosphofructokinases (PFK; EC 2.7.1.11) are tetrameric enzymes that have a key role in the regulation of glycolysis; as such, they are subject to allosteric activation and inhibition by various metabolites. Eukaryotic PFKs are about twice the size of prokaryotic enzymes and are regulated by a wider repertoire of effectors: for example, the subunit molecular weights of rabbit muscle (RM) PFK and Bacillus stearothermophilus (Bs) PFK are 82,000 and 36,000, respectively. Both enzymes are activated by ADP (or AMP), but RM-PFK is also activated by fructose bisphosphates (FBP) and inhibited by ATP and citrate. This, together with other evidence, has led to speculation that mammalian PFKs have evolved by duplication of a prokaryotic gene, although previous peptide analysis failed to reveal internal homology in RM-PFK. Here we demonstrate clear homology among the N- and C-halves of RM-PFK and Bs-PFK, thus establishing an evolutionary relationship by series gene duplication and divergence. Furthermore, detailed knowledge of the Bs-PFK structure provides the basis for inferences concerning the structural organization of RM-PFK and the evolution of new effector sites in the enzyme tetramer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/309467a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2460807", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2460502", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5967", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "309"
      }
    ], 
    "name": "Evolution of phosphofructokinase\u2014gene duplication and creation of new effector sites", 
    "pagination": "467-469", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0c378f203f1d883948dc9f70c1d2046ea8837ffcc297da0a3ea25c6e8672061f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6233492"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/309467a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002565920"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/309467a0", 
      "https://app.dimensions.ai/details/publication/pub.1002565920"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/309467a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/309467a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/309467a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/309467a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/309467a0'


 

This table displays all metadata directly associated to this object as RDF triples.

185 TRIPLES      21 PREDICATES      59 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/309467a0 schema:about N1a19152388584de68b6816226bd529c3
2 N1db265ddc6db4fa7af21b7eb51afe1a8
3 N29f62b0296b04777982c6cf4bdea8a3c
4 N3f5dc2acbe594c3abc859613ffcd7738
5 N4594596216cc45b980c545e77bcad611
6 N8a1c2f03d94747b297ae3576c85a91e2
7 N90fc657f05524030989e2e7f0668f75a
8 N954a829557f542d88ab7ee71ee46316c
9 Ndf864c8978af4a638070ad85d989af76
10 Ne385e655fe934399a68681e1ab3acfaa
11 Nf42c180b7d064a0198a11137c7e78076
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author N7e8f5fd3755d4f58a1714c39e2dc2e9b
15 schema:citation sg:pub.10.1007/bf00849191
16 sg:pub.10.1038/279500a0
17 https://app.dimensions.ai/details/publication/pub.1080203838
18 https://app.dimensions.ai/details/publication/pub.1080236926
19 https://app.dimensions.ai/details/publication/pub.1081651972
20 https://app.dimensions.ai/details/publication/pub.1081748086
21 https://app.dimensions.ai/details/publication/pub.1081750828
22 https://doi.org/10.1002/9780470122938.ch4
23 https://doi.org/10.1016/0003-9861(74)90027-7
24 https://doi.org/10.1016/0022-2836(68)90316-1
25 https://doi.org/10.1016/0022-2836(70)90372-4
26 https://doi.org/10.1016/0022-2836(81)90227-8
27 https://doi.org/10.1021/bi00274a014
28 https://doi.org/10.1021/bi00288a039
29 https://doi.org/10.1021/bi00673a003
30 https://doi.org/10.1021/bi00746a001
31 https://doi.org/10.1021/bi00854a009
32 https://doi.org/10.1111/j.1432-1033.1976.tb10785.x
33 https://doi.org/10.1111/j.1432-1033.1980.tb04754.x
34 schema:datePublished 1984-05
35 schema:datePublishedReg 1984-05-01
36 schema:description Phosphofructokinases (PFK; EC 2.7.1.11) are tetrameric enzymes that have a key role in the regulation of glycolysis; as such, they are subject to allosteric activation and inhibition by various metabolites. Eukaryotic PFKs are about twice the size of prokaryotic enzymes and are regulated by a wider repertoire of effectors: for example, the subunit molecular weights of rabbit muscle (RM) PFK and Bacillus stearothermophilus (Bs) PFK are 82,000 and 36,000, respectively. Both enzymes are activated by ADP (or AMP), but RM-PFK is also activated by fructose bisphosphates (FBP) and inhibited by ATP and citrate. This, together with other evidence, has led to speculation that mammalian PFKs have evolved by duplication of a prokaryotic gene, although previous peptide analysis failed to reveal internal homology in RM-PFK. Here we demonstrate clear homology among the N- and C-halves of RM-PFK and Bs-PFK, thus establishing an evolutionary relationship by series gene duplication and divergence. Furthermore, detailed knowledge of the Bs-PFK structure provides the basis for inferences concerning the structural organization of RM-PFK and the evolution of new effector sites in the enzyme tetramer.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N1e2e9f2d491d482baffff0476896ded3
41 N60263439605a492dadb952b45c33b93b
42 sg:journal.1018957
43 schema:name Evolution of phosphofructokinase—gene duplication and creation of new effector sites
44 schema:pagination 467-469
45 schema:productId N3d334a39230e4ddaaccdf73929ad32f9
46 N60002b2b693e4668b45aed482a4a9700
47 N87c7cda2b2ed4a1aa4dacc1bbbb4caa6
48 N996150a5c1094092ae855e09d238f4a2
49 Neec3fe1e5c4f4fec96cc5b6906e30a89
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002565920
51 https://doi.org/10.1038/309467a0
52 schema:sdDatePublished 2019-04-10T23:11
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N7be5f9282ba54535a9314b01d333baf4
55 schema:url http://www.nature.com/articles/309467a0
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N1a19152388584de68b6816226bd529c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Phosphofructokinase-1
61 rdf:type schema:DefinedTerm
62 N1db265ddc6db4fa7af21b7eb51afe1a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Animals
64 rdf:type schema:DefinedTerm
65 N1e2e9f2d491d482baffff0476896ded3 schema:issueNumber 5967
66 rdf:type schema:PublicationIssue
67 N29f62b0296b04777982c6cf4bdea8a3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Amino Acid Sequence
69 rdf:type schema:DefinedTerm
70 N3d334a39230e4ddaaccdf73929ad32f9 schema:name doi
71 schema:value 10.1038/309467a0
72 rdf:type schema:PropertyValue
73 N3f5dc2acbe594c3abc859613ffcd7738 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Geobacillus stearothermophilus
75 rdf:type schema:DefinedTerm
76 N4594596216cc45b980c545e77bcad611 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Muscles
78 rdf:type schema:DefinedTerm
79 N54147aab3a3d45b1be507eb8edba5114 rdf:first sg:person.01333234315.23
80 rdf:rest N965e10d46aeb4f6783a97aee58220b8e
81 N60002b2b693e4668b45aed482a4a9700 schema:name nlm_unique_id
82 schema:value 0410462
83 rdf:type schema:PropertyValue
84 N60263439605a492dadb952b45c33b93b schema:volumeNumber 309
85 rdf:type schema:PublicationVolume
86 N7be5f9282ba54535a9314b01d333baf4 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N7e8f5fd3755d4f58a1714c39e2dc2e9b rdf:first sg:person.0752620410.41
89 rdf:rest N54147aab3a3d45b1be507eb8edba5114
90 N87c7cda2b2ed4a1aa4dacc1bbbb4caa6 schema:name pubmed_id
91 schema:value 6233492
92 rdf:type schema:PropertyValue
93 N8a1c2f03d94747b297ae3576c85a91e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Rabbits
95 rdf:type schema:DefinedTerm
96 N90fc657f05524030989e2e7f0668f75a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Biological Evolution
98 rdf:type schema:DefinedTerm
99 N954a829557f542d88ab7ee71ee46316c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Macromolecular Substances
101 rdf:type schema:DefinedTerm
102 N965e10d46aeb4f6783a97aee58220b8e rdf:first sg:person.01173533437.51
103 rdf:rest Nccc3e2679e9a417cb4b8d7d42acb8b06
104 N996150a5c1094092ae855e09d238f4a2 schema:name dimensions_id
105 schema:value pub.1002565920
106 rdf:type schema:PropertyValue
107 Nccc3e2679e9a417cb4b8d7d42acb8b06 rdf:first sg:person.073472130.52
108 rdf:rest rdf:nil
109 Ndf864c8978af4a638070ad85d989af76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Models, Molecular
111 rdf:type schema:DefinedTerm
112 Ne385e655fe934399a68681e1ab3acfaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Species Specificity
114 rdf:type schema:DefinedTerm
115 Neec3fe1e5c4f4fec96cc5b6906e30a89 schema:name readcube_id
116 schema:value 0c378f203f1d883948dc9f70c1d2046ea8837ffcc297da0a3ea25c6e8672061f
117 rdf:type schema:PropertyValue
118 Nf42c180b7d064a0198a11137c7e78076 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Protein Conformation
120 rdf:type schema:DefinedTerm
121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
122 schema:name Biological Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
125 schema:name Genetics
126 rdf:type schema:DefinedTerm
127 sg:grant.2460502 http://pending.schema.org/fundedItem sg:pub.10.1038/309467a0
128 rdf:type schema:MonetaryGrant
129 sg:grant.2460807 http://pending.schema.org/fundedItem sg:pub.10.1038/309467a0
130 rdf:type schema:MonetaryGrant
131 sg:journal.1018957 schema:issn 0090-0028
132 1476-4687
133 schema:name Nature
134 rdf:type schema:Periodical
135 sg:person.01173533437.51 schema:familyName Kemp
136 schema:givenName Robert G.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173533437.51
138 rdf:type schema:Person
139 sg:person.01333234315.23 schema:familyName Randolph
140 schema:givenName Anne
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333234315.23
142 rdf:type schema:Person
143 sg:person.073472130.52 schema:familyName Heinrikson
144 schema:givenName Robert L.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073472130.52
146 rdf:type schema:Person
147 sg:person.0752620410.41 schema:familyName Poorman
148 schema:givenName Roger A.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752620410.41
150 rdf:type schema:Person
151 sg:pub.10.1007/bf00849191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013139564
152 https://doi.org/10.1007/bf00849191
153 rdf:type schema:CreativeWork
154 sg:pub.10.1038/279500a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051644922
155 https://doi.org/10.1038/279500a0
156 rdf:type schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1080203838 schema:CreativeWork
158 https://app.dimensions.ai/details/publication/pub.1080236926 schema:CreativeWork
159 https://app.dimensions.ai/details/publication/pub.1081651972 schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1081748086 schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1081750828 schema:CreativeWork
162 https://doi.org/10.1002/9780470122938.ch4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037133383
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/0003-9861(74)90027-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032674261
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/0022-2836(68)90316-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010887142
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0022-2836(70)90372-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033069770
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/0022-2836(81)90227-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294391
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1021/bi00274a014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055168183
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1021/bi00288a039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055168802
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1021/bi00673a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055184819
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1021/bi00746a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055187214
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1021/bi00854a009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055191144
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1111/j.1432-1033.1976.tb10785.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012231114
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1111/j.1432-1033.1980.tb04754.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053213746
185 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...