Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-05

AUTHORS

Shigeru Katamine, Masayuki Otsu, Kotaro Tada, Shigeru Tsuchiya, Tetsuo Sato, Nakao Ishida, Tasuku Honjo, Yasushi Ono

ABSTRACT

The very early stages of the human B-cell differentiation pathway are poorly understood, primarily because of the lack of appropriate permanent cell lines. Epstein–Barr virus (EBV) is a putative human oncogenic virus which transforms human B cells in vitro into continuously proliferating cells1. It has been believed that EBV transforms mature B cells2,3 but recently, transformation of immature pre-B-cell lines has been reported4–6, suggesting that EBV might also transform cells much earlier in the B-cell lineage. We report here the establishment of cell lines transformed by EBV at various stages of the B-cell differentiation pathway. Interestingly, two lines showed the complete absence of immunoglobulin synthesis and the lack of immunoglobulin gene rearrangement despite containing EBV genome and surface markers of B cells. Our results indicate that EBV can infect and tranform cells of the B lymphocyte lineage even before immunoglobulin gene rearrangement. More... »

PAGES

369-372

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/309369a0

DOI

http://dx.doi.org/10.1038/309369a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048268602

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6328311


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