Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-04

AUTHORS

Daniel J. Donoghue, Crystal Anderson, Tony Hunter, Paul L. Kaplan

ABSTRACT

Polyoma virus is a papovavirus that productively infects mouse cells. In cells of other species, such as rat cells, polyoma virus is virtually unable to replicate, and a small proportion of infected cells become stably transformed. The ability of polyoma virus to transform infected cells is determined by genes that encode the large, middle and small T antigens1–3 and which are found in the early region of the virus genome. We have inserted the transforming region of polyoma virus into a murine leukaemia virus (MLV) vector, to generate a replication-defective transforming retrovirus which for the first time allows efficient transformation of mouse cells by the polyoma virus middle T gene. During the life cycle of this recombinant virus the intervening sequence present in the original polyoma virus middle T gene was removed. The recombinant virus that we have constructed is analogous to other acutely transforming retroviruses, and demonstrates that the polyoma middle T gene is a dominant transforming oncogene. More... »

PAGES

748-750

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/308748a0

DOI

http://dx.doi.org/10.1038/308748a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052242821

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6325917


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