A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-03

AUTHORS

Yusuke Yanagi, Yasunobu Yoshikai, Kathleen Leggett, Stephen P. Clark, Ingrid Aleksander, Tak W. Mak

ABSTRACT

We have cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells. The message was found to be expressed in human and murine T lymphoblasts, thymocytes and phytohaemagglutinin-stimulated T lymphocytes. The protein deduced from the cDNA sequence has a molecular weight of 34,938 and shows extensive similarity to the entire length of the variable, joining and constant regions of mammalian immunoglobulin light chains. In addition, the relative positions of the cysteine residues are similar to those of the light chains of murine and human immunoglobulin molecules. These properties suggest that the cDNA clone may correspond to a message that specifies part of the human T-cell receptor. More... »

PAGES

145-149

Journal

TITLE

Nature

ISSUE

5955

VOLUME

308

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/308145a0

    DOI

    http://dx.doi.org/10.1038/308145a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021425337

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6336315


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