Correlation between segmental flexibility and effector function of antibodies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-01

AUTHORS

V. T. Oi, T. M. Vuong, R. Hardy, J. Reidler, J. Dangl, L. A. Herzenberg, L. Stryer

ABSTRACT

Mouse monoclonal anti-dansyl antibodies with the same antigen-binding sites but different heavy chain constant regions were generated. The extent of segmental flexibility in times of nanoseconds and the capacity to fix complement were greatest for IgG2b, intermediate for IgG2a, and least for IgG1 and IgE. Hence, the effector functions of immunoglobulin isotypes may be controlled in part by the freedom of movement of their Fab arms. More... »

PAGES

136-140

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/307136a0

DOI

http://dx.doi.org/10.1038/307136a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039967086

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6690993


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