β-Adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-12

AUTHORS

David C. Gadsby

ABSTRACT

Hormonal modulation of the ionic conductance of cell membranes is a topic of considerable current interest1–3; it has a major role, for example, in the improved performance of the vertebrate heart elicited by sympathetic nerve stimulation or by circulating catecholamines, an effect involving enhanced calcium influx3–6. β-Agonist catecholamines also abbreviate the action potential of cardiac Purkinje fibres7–11, and increase the resting potential in a variety of cells12–14, including cardiac cells7,10,15–17, a hyperpolarization usually attributed to stimulation of the electrogenic Na+/K+ pump. We show here that nanomolar concentrations of β-catecholamines cause hyperpolarization of cardiac Purkinje fibres, not by increasing Na+/K+ pump current, but by increasing resting membrane K+ conductance. The hyperpolarization and shortening of the action potential should increase availability of Na+ channels and reduce the refractory period, effects tending to safeguard impulse propagation through the ventricular conducting system despite the increased heart rate caused by β-catecholamine action on the sinus node pacemaker. More... »

PAGES

691-693

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/306691a0

DOI

http://dx.doi.org/10.1038/306691a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003129637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6140641


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