β-Globin gene inactivation by DNA translocation in γβ-thalassaemi View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-12

AUTHORS

D Kioussis, E Vanin, T deLange, R A Flavell, F G Grosveld

ABSTRACT

The beta-globin gene present on the deletion locus in a Dutch gamma beta-thalassaemic patient was found to be identical to the normal beta-globin gene with respect to DNA sequence and its transcription in HeLa cells. DNase I sensitivity and methylation experiments show that the affected beta-globin gene is present in an inactive configuration in vivo. This is the result of a translocation of a normally inactive locus next to the beta-globin gene on the affected chromosome, or the deletion of sequences which are normally required for the maintenance of the active state. More... »

PAGES

662-666

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/306662a0

DOI

http://dx.doi.org/10.1038/306662a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026221696

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6318113


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