Reversible induction of natural killer cell activity in cloned murine cytotoxic T lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1983-09

AUTHORS

Colin G. Brooks

ABSTRACT

Natural killer (NK) activity is a poorly understood component of the immune system, generally identified as the ability to kill certain tumour cells1,2. Perhaps the most controversial issue has been the lineage to which cells displaying this activity belong. Extensive studies of surface antigens on cells with NK activity in both mouse and man have led to enigmatic results, such cells apparently bearing markers of both T-cell (Thy-1 and E receptor) and myeloid (Mac-1 and OKM1) lineages3–6. A fresh approach to this problem would be to take cells of known lineage and test whether they express, or could be induced to express, NK cell function. Using this approach we show here that monoclonal cytotoxic T lymphocyte (CTL) lines can be induced, by culture in high concentrations of spleen cell supernatant, to express a new lytic activity apparently identical with that of splenic cells NK activity. Preliminary evidence implicates both interleukin-2(IL-2) and interferon (IFN) as mediators of this phenomenon. These findings clearly demonstrate that cells of T cell lineage have the capacity to express NK activity. More... »

PAGES

155-158

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/305155a0

DOI

http://dx.doi.org/10.1038/305155a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045141074

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6604229


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