Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-08

AUTHORS

John P. McGrath, Daniel J. Capon, Douglas H. Smith, Ellson Y. Chen, Peter H. Seeburg, David V. Goeddel, Arthur D. Levinson

ABSTRACT

Analysis of the organization and nucleotide sequence of two human loci related to the transforming gene of Kirsten murine sarcoma virus establishes one as a functional gene and the other as a processed pseudogene. The two final coding exons of the functional gene seem to have arisen by duplication. Differentially spliced mRNAs incorporating one or other of the duplicated exons probably served as the intermediates by which the viral transforming gene and the pseudogene were generated. This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing. More... »

PAGES

501-506

References to SciGraph publications

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  • 1983-03. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    5926

    VOLUME

    304

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/304501a0

    DOI

    http://dx.doi.org/10.1038/304501a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013233069

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6308466


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