Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-08

AUTHORS

Kenji Shimizu, Daniel Birnbaum, Mary Ann Ruley, Ottavio Fasano, Yolande Suard, Louise Edlund, Elizabeth Taparowsky, Mitchell Goldfarb, Michael Wigler

ABSTRACT

The homologue of the viral Kirsten ras (ν-Ki-ras) gene found in the human lung carcinoma cell line, Calu-1, has an intron–exon structure similar to that of the human homologue of the viral Harvey ras (v-Ha-ras) gene. A second, potential fourth coding exon is present in the human Ki-ras gene and similar sequences are found in the Kirsten murine sarcoma virus. Cysteine is encoded at the twelfth amino acid position, suggesting that the Calu-1 Ki-ras gene has undergone a mutational activation at the same position as the human Ha-ras gene of the bladder carcinoma cell line, T24. A comparison of their predicted amino acid sequences suggests that ras proteins have a ‘constant’ region and a ‘variable’ region. Here we propose a common modular structure for ras gene products in which the variable region forms a physiologically important combining site. More... »

PAGES

497-500

Journal

TITLE

Nature

ISSUE

5926

VOLUME

304

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/304497a0

    DOI

    http://dx.doi.org/10.1038/304497a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016009229

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6308465


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